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Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues
Yu MR; Wang JL; Yang YW; Zhu CL; Su Q; Guo SY; Sun JS; Gan Y; Shi XH(施兴华); Gao HJ; Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.; Gan, Y; Shi, XH (reprint author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.; Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
Source PublicationNANO LETTERS
2016
Volume16Issue:11Pages:7176-7182
ISSN1530-6984
AbstractMucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles. (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.
KeywordMucus Penetration Nanoparticle Diffusion Shape Dependent Molecular Simulations Transmucosal Delivery
DOI10.1021/acs.nanolett.6b03515
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000387625000067
WOS KeywordMucus penetration ; nanoparticle diffusion ; shape dependent ; molecular simulations ; transmucosal delivery
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China [81373356, 81573378, 11422215, 11272327, 11672079] ; "Science and technology innovation action plan for basic research" of Shanghai [14JC1493200] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0120153020]
Classification一类
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Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59956
Collection非线性力学国家重点实验室
Corresponding AuthorGan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.; Gan, Y; Shi, XH (reprint author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.; Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
Recommended Citation
GB/T 7714
Yu MR,Wang JL,Yang YW,et al. Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues[J]. NANO LETTERS,2016,16(11):7176-7182.
APA Yu MR.,Wang JL.,Yang YW.,Zhu CL.,Su Q.,...&Gao, HJ .(2016).Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues.NANO LETTERS,16(11),7176-7182.
MLA Yu MR,et al."Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues".NANO LETTERS 16.11(2016):7176-7182.
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