Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues

doi:10.1021/acs.nanolett.6b03515

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	Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues
	Yu MR; Wang JL; Yang YW; Zhu CL; Su Q; Guo SY; Sun JS; Gan Y; Shi XH(施兴华); Gao HJ; Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.; Gan, Y; Shi, XH (reprint author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.; Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
发表期刊	NANO LETTERS
	2016
卷号	16 期号:11 页码:7176-7182
ISSN	1530-6984
摘要	Mucus is a viscoelastic gel layer that typically protects exposed surfaces of the gastrointestinal (GI) tract, lung airways, and other mucosal tissues. Particles targeted to these tissues can be efficiently trapped and removed by mucus, thereby limiting the effectiveness of such drug delivery systems. In this study, we experimentally and theoretically demonstrated that cylindrical nanoparticles. (NPs), such as mesoporous silica nanorods and calcium phosphate nanorods, have superior transport and trafficking capability in mucus compared with spheres of the same chemistry. The higher diffusivity of nanorods leads to deeper mucus penetration and a longer retention time in the GI tract than that of their spherical counterparts. Molecular simulations and stimulated emission of depletion (STED) microscopy revealed that this anomalous phenomenon can be attributed to the rotational dynamics of the NPs facilitated by the mucin fibers and the shear flow. These findings shed new light on the shape design of NP-based drug delivery systems targeted to mucosal and tumor sites that possess a fibrous structure/porous medium.
关键词	Mucus Penetration Nanoparticle Diffusion Shape Dependent Molecular Simulations Transmucosal Delivery
DOI	10.1021/acs.nanolett.6b03515
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000387625000067
关键词[WOS]	Mucus penetration ; nanoparticle diffusion ; shape dependent ; molecular simulations ; transmucosal delivery
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者	National Natural Science Foundation of China [81373356, 81573378, 11422215, 11272327, 11672079] ; "Science and technology innovation action plan for basic research" of Shanghai [14JC1493200] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0120153020]
论文分区	一类
引用统计	被引频次：127[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/59956
专题	非线性力学国家重点实验室
通讯作者	Gan, Y (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Nanosyst & Hierarchy Fabricat, Ctr Excellence Nanosci, Beijing 100190, Peoples R China.; Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.; Gan, Y; Shi, XH (reprint author), Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China.; Gao, HJ (reprint author), Brown Univ, Sch Engn, Providence, RI 02912 USA.
推荐引用方式 GB/T 7714	Yu MR,Wang JL,Yang YW,et al. Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues[J]. NANO LETTERS,2016,16,11,:7176-7182.
APA	Yu MR.,Wang JL.,Yang YW.,Zhu CL.,Su Q.,...&Gao, HJ .(2016).Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues.NANO LETTERS,16(11),7176-7182.
MLA	Yu MR,et al."Rotation-Facilitated Rapid Transport of Nanorods in Mucosal Tissues".NANO LETTERS 16.11(2016):7176-7182.

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