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Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions
Li L(李龙); Xu GK; Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Source PublicationPHYSICAL REVIEW E
2017
Volume95Issue:1Pages:12403
ISSN2470-0045
AbstractThe interactions between T-cell receptor (TCR) and peptide-major-histocompatibility complex (pMHC), which enable T-cell development and initiate adaptive immune responses, have been intensively studied. However, a central issue of how lipid rafts affect the TCR-pMHC interactions remains unclear. Here, by using a statistical-mechanical membrane model, we show that the binding affinity of TCR and pMHC anchored on two apposing cell membranes is significantly enhanced because of the lipid raft-induced signaling protein aggregation. This finding may provide an alternative insight into the mechanism of T-cell activation triggered by very low densities of pMHC. In the case of cell-substrate adhesion, our results indicate that the loss of lateral mobility of the proteins on the solid substrate leads to the inhibitory effect of lipid rafts on TCR-pMHC interactions. Our findings help to understand why different experimental methods for measuring the impact of lipid rafts on the receptor-ligand interactions have led to contradictory conclusions.
DOI10.1103/PhysRevE.95.012403
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000391864200007
WOS Research AreaPhysics
WOS SubjectPhysics, Fluids & Plasmas ; Physics, Mathematical
Funding OrganizationPrograms in the National Natural Science Foundation of China [11472285, 11232013, 11402193] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB22040102] ; National Key Research and Development Program of China [2016YFA0501601]
DepartmentLNM生物材料微结构和力学性能
Classification一类
Ranking1
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59959
Collection非线性力学国家重点实验室
Corresponding AuthorSong, F (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Li L,Xu GK,Song F,et al. Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions[J]. PHYSICAL REVIEW E,2017,95(1):12403.
APA 李龙,Xu GK,宋凡,Song, F ,Song, F ,&Song, F .(2017).Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions.PHYSICAL REVIEW E,95(1),12403.
MLA 李龙,et al."Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions".PHYSICAL REVIEW E 95.1(2017):12403.
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