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Title: Impact of lipid rafts on the T-cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions
Author: Li L(李龙); Xu GK; Song F(宋凡)
Source: PHYSICAL REVIEW E
Issued Date: 2017
Volume: 95, Issue:1, Pages:12403
Abstract: The interactions between T-cell receptor (TCR) and peptide-major-histocompatibility complex (pMHC), which enable T-cell development and initiate adaptive immune responses, have been intensively studied. However, a central issue of how lipid rafts affect the TCR-pMHC interactions remains unclear. Here, by using a statistical-mechanical membrane model, we show that the binding affinity of TCR and pMHC anchored on two apposing cell membranes is significantly enhanced because of the lipid raft-induced signaling protein aggregation. This finding may provide an alternative insight into the mechanism of T-cell activation triggered by very low densities of pMHC. In the case of cell-substrate adhesion, our results indicate that the loss of lateral mobility of the proteins on the solid substrate leads to the inhibitory effect of lipid rafts on TCR-pMHC interactions. Our findings help to understand why different experimental methods for measuring the impact of lipid rafts on the receptor-ligand interactions have led to contradictory conclusions.
Language: 英语
Indexed Type: SCI ; EI
Corresponding Author: Song, F (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China. ; Song, F (reprint author), Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China. ; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Correspondent Email: songf@lnm.imech.ac.cn
DOI: 10.1103/PhysRevE.95.012403
Related URLs: 查看原文
DOC Type: 期刊论文
WOS Subject: Physics, Fluids & Plasmas ; Physics, Mathematical
WOS Subject Extended: Physics
WOS ID: WOS:000391864200007
ISSN: 2470-0045
Funder: Programs in the National Natural Science Foundation of China [11472285, 11232013, 11402193] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB22040102] ; National Key Research and Development Program of China [2016YFA0501601]
Rank: [Li, Long; Song, Fan] Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China; [Li, Long; Song, Fan] Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing 100190, Peoples R China; [Xu, Guang-Kui] Xi An Jiao Tong Univ, Sch Aerosp, State Key Lab Strength & Vibrat Mech Struct, Int Ctr Appl Mech, Xian 710049, Peoples R China; [Song, Fan] Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
Department: LNM生物材料微结构和力学性能
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/59959
Appears in Collections:非线性力学国家重点实验室_期刊论文

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