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Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning
Liu C; Ding BQ; Xue CD; Tian Y; Hu GQ(胡国庆); Su JS; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.; Hu, GQ (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.; Su, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Source PublicationANALYTICAL CHEMISTRY
2016
Volume88Issue:24Pages:12547-12553
ISSN0003-2700
AbstractViscoelastic microfluidics becomes an efficient and label free hydrodynamic technology to enrich and separate micrometer-scale particles, including blood cells, circulating tumor cells, and bacteria. However, the manipulation of nanoscale particles by viscoelastic microfluidics remains a major challenge, because the viscoelastic force acting on the smaller particle decreases dramatically. In contrast to the commonly used polymer solutions of high molecular weight, herein we utilize the aqueous solutions of poly(ethylene oxide) (PEO) of low molecular weight with minimized shear thinning but sufficient elastic force for high-quality focusing and separation of various nanoparticles. The focusing efficiencies of 100 nm polystyrene (PS) nanoparticles and 2-DNA molecules are 84% and 85%, respectively, in a double spiral microchannel, without the aid of sheath flows. Furthermore, we demonstrate the size-based viscoelastic separation of two sets of binary mixtures-100/2000 nm PS particles and 2-DNA molecules/blood platelets all achieving separation efficiencies of >95% in the same device. Our proposal technique would be a promising approach for enrichment/separation of the nanoparticles encountered in applications of analytical chemistry and nanotechnology.
DOI10.1021/acs.analchem.6b04564
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Indexed BySCI
Language英语
WOS IDWOS:000390621000078
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding OrganizationNSFC [11572334, 91543125, 11272321, 21475028, 21622503] ; CAS [QYZDB-SSW-JSC036, XDB22040403] ; MOST [2013AA032204] ; Youth Innovation Promotion Association CAS
DepartmentLNM微纳米流体力学
Classification一类
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/59974
Collection非线性力学国家重点实验室
Corresponding AuthorHu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.; Hu, GQ (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.; Su, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Liu C,Ding BQ,Xue CD,et al. Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning[J]. ANALYTICAL CHEMISTRY,2016,88(24):12547-12553.
APA Liu C.,Ding BQ.,Xue CD.,Tian Y.,胡国庆.,...&Su, JS .(2016).Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning.ANALYTICAL CHEMISTRY,88(24),12547-12553.
MLA Liu C,et al."Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning".ANALYTICAL CHEMISTRY 88.24(2016):12547-12553.
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