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Application of supported phospholipids bilayer bilayers for biosensor based on imaging ellipsometry
Chen YY; Zhang YB; Wang CX; Ding ZJ; Huang CH; Chang WR; Jin G(靳刚); Chang, W. R. (wrchang@sun5.ibp.ac.cn)
Source PublicationIFMBE Proceedings
2009
Conference NameWorld Congress on Medical Physics and Biomedical Engineering: Micro- and Nanosystems in Medicine, Active Implants, Biosensors
Conference DateSeptember 7, 2009 - September 12, 2009
Conference PlaceMunich, Germany
AbstractApplication of supported phospholipids bilayers (SPB) is presented for biosensor based on imaging ellipsometry. One SPB is prepared by covalent immobilization of phospholipids monolayer on silicon surface, and followed by adsorption of PEG functionalized phospholipids layer. Another is prepared by adsorption of the mixture of phospholipids and PEG functionalized phospholipids on the hydrophilic silicon surface. Results show that obvious resistance to non-specific protein adsorption on SPB is obtained, and proteins covalently immobilized on the bilayers by the terminal carboxyl group of PEG remain higher bioactivity than that immobilized on silicon surface directly. © 2009 Springer-Verlag.
KeywordBi-layer Carboxyl Groups Covalent Immobilization Functionalized Imaging Ellipsometry Microfiuidic Array Non-specific Protein Adsorption Phospholipids Bilayer Silicon Surfaces Supported Phospholipid Bilayers
ISBN9783642038860
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Indexed ByEI
Language英语
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60454
Collection国家微重力实验室
Corresponding AuthorChang, W. R. (wrchang@sun5.ibp.ac.cn)
Recommended Citation
GB/T 7714
Chen YY,Zhang YB,Wang CX,et al. Application of supported phospholipids bilayer bilayers for biosensor based on imaging ellipsometry[C],2009.
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