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Study on the deformations of the lamina cribrosa during glaucoma
Tian HJ(田晗菁); Li L(李龙); Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
Source PublicationACTA BIOMATERIALIA
2017-06-01
Volume55Pages:340-348
ISSN1742-7061
AbstractThe lamina cribrosa is the primary site of optic nerve injury during glaucoma and its deformations induced by elevated intraocular pressure are associated directly with the optic nerve injury and visual field defect. However the deformations in a living body have been poorly understood yet so far. It is because that integral observation and precise measurement of the deformations in vivo are now almost impossible in the clinical diagnosis and treatment of glaucoma. In the present study a new mechanical model of the lamina cribrosa is presented by using Reissner's thin plate theory. This model accurately displays the stress and deformation states in the lamina cribrosa under elevated intraocular pressure in which the shear deformation is not presented by the previous models however is demonstrated to play a key role in the optic nerve injury. Further the deformations of the structures involving the optic nerve channels and the laminar sheets in the lamina cribrosa are first investigated in detail. For example the dislocation of the laminar sheets reaches 18.6 mu m under the intraocular pressure of 40 mmHg which is large enough to damage the optic nerve axons. The results here confirm some previously proposed clinical speculations on the deformations of the pore shape in the lamina cribrosa under elevated intraocular pressure during glaucoma. Finally some essentially clinical questions existed during glaucoma such as the pathological mechanism of the open-angle glaucoma with normal intraocular pressure are discussed. The present study is beneficial to deeply understanding the optic nerve injury during glaucoma.
KeywordLamina Cribrosa Glaucoma Deformation Optic Nerve Injury Reissner's Thin Plate Theory
DOI10.1016/j.actbio.2017.03.028
Indexed BySCI
Language英语
WOS IDWOS:000403414500026
WOS KeywordOPTIC-NERVE HEAD ; INTRAOCULAR-PRESSURE ELEVATION ; OPEN-ANGLE GLAUCOMA ; MATHEMATICAL-MODEL ; HUMAN EYES ; BIOMECHANICS ; DAMAGE ; DISEASE ; DISC
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China(11232013 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB22040102) ; National Key Research and Development Program of China - China(2016YFA0501601) ; 11472285)
DepartmentLNM生物材料微结构和力学性能
Classification一类
Ranking1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60512
Collection非线性力学国家重点实验室
Corresponding AuthorSong, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Tian HJ,Li L,Song F,et al. Study on the deformations of the lamina cribrosa during glaucoma[J]. ACTA BIOMATERIALIA,2017,55:340-348.
APA 田晗菁,李龙,宋凡,&Song, F .(2017).Study on the deformations of the lamina cribrosa during glaucoma.ACTA BIOMATERIALIA,55,340-348.
MLA 田晗菁,et al."Study on the deformations of the lamina cribrosa during glaucoma".ACTA BIOMATERIALIA 55(2017):340-348.
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