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Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands
Li L(李龙); Hu JL; Shi XH(施兴华); Shao YF(邵颖峰); Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mech, Beijing 100190, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Jiangsu, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Source PublicationSOFT MATTER
2017-06-21
Volume13Issue:23Pages:4294-4304
ISSN1744-683X
AbstractGaining insights into the binding of membrane-anchored receptors and ligands that mediate cell adhesion and signal transduction is of great significance for understanding numerous physiological processes driven by intercellular communication. Lipid rafts microdomains in cell membranes enriched in cholesterol and saturated lipids such as sphingomyelin are believed to serve as the essential platforms to recruit protein molecules for biological functions. An important question remains how the lipid rafts affect the binding constant of membrane-anchored receptors and ligands. We have investigated the adhesion of multicomponent membranes by using Monte Carlo simulations of a mesoscopic model with biologically relevant parameters. We find that the preferential partitioning of membrane-anchored receptor and ligand proteins in the lipid rafts significantly increases the binding constant of those proteins in cooperation with the shape fluctuations of the membranes caused by thermal excitations. The binding constant can even be greater than that of the same receptors and ligands anchored to two apposing supported planar membranes without shape fluctuations. The membrane shape fluctuations facilitate the binding of the anchored receptors and ligands in contrast to the case of homogeneous membranes. Our results suggest that cells might regulate the binding of membrane-anchored receptor and ligand proteins by modulating the properties of lipid rafts such as area fraction size and the affinity of rafts to the proteins.
DOI10.1039/c7sm00572e
Indexed BySCI ; EI
Language英语
WOS IDWOS:000403433600012
WOS Keyword2-DIMENSIONAL DISSOCIATION-CONSTANT ; CELL-ADHESION MOLECULES ; LATERAL DIFFUSION ; CONTACT AREA ; CATCH BONDS ; KINETICS ; TCR ; INSIGHTS ; ROUGHNESS ; PROTEINS
WOS Research AreaChemistry ; Materials Science ; Physics ; Polymer Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China(11472285 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB22040102) ; National Key Research and Development Program of China(2016YFA0501601) ; Fundamental Research Funds for the Central Universities and Shenzhen Science and Technology Innovation Committee(JCYJ20160531151105346) ; 11232013 ; 21504038)
DepartmentLNM生物材料微结构和力学性能
Classification一类
Ranking1
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60527
Collection非线性力学国家重点实验室
Corresponding AuthorSong, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mech, Beijing 100190, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Jiangsu, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Li L,Hu JL,Shi XH,et al. Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands[J]. SOFT MATTER,2017,13(23):4294-4304.
APA 李龙.,Hu JL.,施兴华.,邵颖峰.,宋凡.,...&Song, F .(2017).Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands.SOFT MATTER,13(23),4294-4304.
MLA 李龙,et al."Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands".SOFT MATTER 13.23(2017):4294-4304.
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