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Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment
Wei JC(韦佳辰); Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
Source PublicationINTERNATIONAL JOURNAL OF MODERN PHYSICS B
2017-01-30
Volume31Issue:3
ISSN0217-9792
AbstractBased on a very simple coarse-grained colloidal model here we implement an effective hard-sphere theory and numerical simulation to capture the general features of the association equilibria for globular proteins in crowded environment. We measure the activity coefficient i.e. the deviation from ideal behavior of protein solution and the crowding factor i.e. the contribution of crowders to the association equilibria for proteins in macromolecular crowding. The results show that the association balance in macro molecular crowding depends sensitively on the magnitude of protein-crowder attraction and the relative size of reactant to crowding agent. Since our coarse-grained model is irrelevant to the microscopic details of the molecules it can be applied to the control of the association equilibria of many globular proteins such as bovine serum albumin crystallin and lysozyme.
KeywordGlobular Protein Association Equilibria Short-range Attraction Macromolecular Crowding
DOI10.1142/S0217979217500072
Indexed BySCI
Language英语
WOS IDWOS:000395314300007
WOS KeywordBOVINE SERUM-ALBUMIN ; LIGHT-SCATTERING ; MODEL ; DEPENDENCE ; REPULSION ; SPHERES
WOS Research AreaPhysics
WOS SubjectPhysics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
Funding OrganizationNational Natural Science Foundation of China(11232013 ; 11472285)
DepartmentLNM生物材料微结构和力学性能
ClassificationQ4
Ranking1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60591
Collection非线性力学国家重点实验室
Corresponding AuthorSong, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Wei JC,Song F,Song, F . Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2017,31(3).
APA 韦佳辰,宋凡,&Song, F .(2017).Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,31(3).
MLA 韦佳辰,et al."Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 31.3(2017).
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