Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment

doi:10.1142/S0217979217500072

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	Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment
	Wei JC(韦佳辰); Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
发表期刊	INTERNATIONAL JOURNAL OF MODERN PHYSICS B
	2017-01-30
卷号	31 期号:3
ISSN	0217-9792
摘要	Based on a very simple coarse-grained colloidal model here we implement an effective hard-sphere theory and numerical simulation to capture the general features of the association equilibria for globular proteins in crowded environment. We measure the activity coefficient i.e. the deviation from ideal behavior of protein solution and the crowding factor i.e. the contribution of crowders to the association equilibria for proteins in macromolecular crowding. The results show that the association balance in macro molecular crowding depends sensitively on the magnitude of protein-crowder attraction and the relative size of reactant to crowding agent. Since our coarse-grained model is irrelevant to the microscopic details of the molecules it can be applied to the control of the association equilibria of many globular proteins such as bovine serum albumin crystallin and lysozyme.
关键词	Globular Protein Association Equilibria Short-range Attraction Macromolecular Crowding
DOI	10.1142/S0217979217500072
收录类别	SCI
语种	英语
WOS记录号	WOS:000395314300007
关键词[WOS]	BOVINE SERUM-ALBUMIN ; LIGHT-SCATTERING ; MODEL ; DEPENDENCE ; REPULSION ; SPHERES
WOS研究方向	Physics
WOS类目	Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
项目资助者	National Natural Science Foundation of China(11232013 ; 11472285)
课题组名称	LNM生物材料微结构和力学性能
论文分区	Q4
力学所作者排名	1
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/60591
专题	非线性力学国家重点实验室
通讯作者	Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Wei JC,Song F,Song, F . Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2017,31,3,.
APA	韦佳辰,宋凡,&Song, F .(2017).Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,31(3).
MLA	韦佳辰,et al."Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 31.3(2017).

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