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Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow
Du Y(杜宇); Peng S(彭爽); Cui Yuhong; Lv SQ(吕守芹); Zhang Y(章燕); Long M(龙勉)
Source PublicationTheoretical and Applied Mechanics Letters
2015
Volume5Issue:6Pages:216-221
ISSN2095-0349
AbstractBlood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor-ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress) and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor-ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions.
KeywordCell Adhesion Aggregation Kinetics Shear Flow
Indexed ByCSCD
Language英语
Funding Organizationsupported by National Natural Science Foundation of China ; National Key Basic Research Foundation of China ; Strategic Priority Research Program
CSCD IDCSCD:5590448
DepartmentNML分子-细胞生物力学与空间生命科学
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60781
Collection国家微重力实验室
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GB/T 7714
Du Y,Peng S,Cui Yuhong,et al. Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow[J]. Theoretical and Applied Mechanics Letters,2015,5(6):216-221.
APA 杜宇,彭爽,Cui Yuhong,吕守芹,章燕,&龙勉.(2015).Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow.Theoretical and Applied Mechanics Letters,5(6),216-221.
MLA 杜宇,et al."Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow".Theoretical and Applied Mechanics Letters 5.6(2015):216-221.
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