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Flow dynamics analyses of pathophysiological liver lobules using porous media theory
Hu JR(胡锦荣); Lv SQ(吕守芹); Feng, Shiliang; Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Source PublicationACTA MECHANICA SINICA
2017-08-01
Volume33Issue:4Pages:823-832
ISSN0567-7718
AbstractBlood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flowrates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules.
KeywordCirrhotic Liver Structural Distortion Portal Hypertension Collateral Vessels
DOI10.1007/s10409-017-0674-7
Indexed BySCI ; EI ; CSCD
Language英语
WOS IDWOS:000406348600013
WOS KeywordHEPATIC BLOOD-FLOW ; MATHEMATICAL-MODEL ; MICROCIRCULATION ; CIRRHOSIS ; FIBROSIS ; DISEASE
WOS Research AreaEngineering ; Mechanics
WOS SubjectEngineering, Mechanical ; Mechanics
Funding OrganizationNational Natural Science Foundation of China(31230027 ; Frontier Science Key Project of Chinese Science Academy(QYZDJ-SSW-JSC018) ; 91642203 ; 31661143044)
DepartmentNML分子-细胞生物力学与空间生命科学
Classification二类
Ranking1
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/60920
Collection国家微重力实验室
Corresponding AuthorLong, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Hu JR,Lv SQ,Feng, Shiliang,et al. Flow dynamics analyses of pathophysiological liver lobules using porous media theory[J]. ACTA MECHANICA SINICA,2017,33(4):823-832.
APA 胡锦荣,吕守芹,Feng, Shiliang,龙勉,Long, M ,&Long, M .(2017).Flow dynamics analyses of pathophysiological liver lobules using porous media theory.ACTA MECHANICA SINICA,33(4),823-832.
MLA 胡锦荣,et al."Flow dynamics analyses of pathophysiological liver lobules using porous media theory".ACTA MECHANICA SINICA 33.4(2017):823-832.
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