Flow dynamics analyses of pathophysiological liver lobules using porous media theory

doi:10.1007/s10409-017-0674-7

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	Flow dynamics analyses of pathophysiological liver lobules using porous media theory
	Hu JR(胡锦荣); Lv SQ(吕守芹); Feng, Shiliang; Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
发表期刊	ACTA MECHANICA SINICA
	2017-08-01
卷号	33 期号:4 页码:823-832
ISSN	0567-7718
摘要	Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flowrates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules.
关键词	Cirrhotic Liver Structural Distortion Portal Hypertension Collateral Vessels
DOI	10.1007/s10409-017-0674-7
收录类别	SCI ; EI ; CSCD
语种	英语
WOS记录号	WOS:000406348600013
关键词[WOS]	HEPATIC BLOOD-FLOW ; MATHEMATICAL-MODEL ; MICROCIRCULATION ; CIRRHOSIS ; FIBROSIS ; DISEASE
WOS研究方向	Engineering ; Mechanics
WOS类目	Engineering, Mechanical ; Mechanics
项目资助者	National Natural Science Foundation of China(31230027 ; Frontier Science Key Project of Chinese Science Academy(QYZDJ-SSW-JSC018) ; 91642203 ; 31661143044)
课题组名称	NML分子-细胞生物力学与空间生命科学
论文分区	二类
力学所作者排名	1
引用统计	被引频次：21[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/60920
专题	微重力重点实验室
通讯作者	Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China.; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
推荐引用方式 GB/T 7714	Hu JR,Lv SQ,Feng, Shiliang,et al. Flow dynamics analyses of pathophysiological liver lobules using porous media theory[J]. ACTA MECHANICA SINICA,2017,33,4,:823-832.
APA	胡锦荣,吕守芹,Feng, Shiliang,龙勉,Long, M ,&Long, M .(2017).Flow dynamics analyses of pathophysiological liver lobules using porous media theory.ACTA MECHANICA SINICA,33(4),823-832.
MLA	胡锦荣,et al."Flow dynamics analyses of pathophysiological liver lobules using porous media theory".ACTA MECHANICA SINICA 33.4(2017):823-832.

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