中国科学院力学研究所机构知识库
Advanced  
IMECH-IR  > 国家微重力实验室  > 期刊论文
Title:
Flow dynamics analyses of pathophysiological liver lobules using porous media theory
Author: Hu JR(胡锦荣); Lv SQ(吕守芹); Feng, Shiliang; Long M(龙勉)
Source: ACTA MECHANICA SINICA
Issued Date: 2017-08-01
Volume: 33, Issue:4, Pages:823-832
Abstract: Blood flow inside the liver plays a key role in hepatic functions, and abnormal hemodynamics are highly correlated with liver diseases. To date, the flow field in an elementary building block of the organ, the liver lobule, is difficult to determine experimentally in humans due to its complicated structure, with radially branched microvasculature and the technical difficulties that derive from its geometric constraints. Here we established a set of 3D computational models for a liver lobule using porous media theory and analyzed its flow dynamics in normal, fibrotic, and cirrhotic lobules. Our simulations indicated that those approximations of ordinary flow in portal tracts (PTs) and the central vein, and of porous media flow in the sinusoidal network, were reasonable only for normal or fibrotic lobules. Models modified with high resistance in PTs and collateral vessels inside sinusoids were able to describe the flow features in cirrhotic lobules. Pressures, average velocities, and volume flowrates were profiled and the predictions compared well with experimental data. This study furthered our understanding of the flow dynamics features of liver lobules and the differences among normal, fibrotic, and cirrhotic lobules.
Keyword: Cirrhotic liver ; Structural distortion ; Portal hypertension ; Collateral vessels
Language: 英语
Indexed Type: SCI ; EI ; CSCD
Corresponding Author: Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Natl Micrograv Lab, Ctr Biomech & Bioengn,Inst Mech,Beijing Key Lab E, Beijing 100190, Peoples R China. ; Long, M (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
Correspondent Email: mlong@imech.ac.cn
DOI: 10.1007/s10409-017-0674-7
DOC Type: Article
WOS Subject: Engineering, Mechanical ; Mechanics
WOS Subject Extended: Engineering ; Mechanics
WOS Keyword Plus: HEPATIC BLOOD-FLOW ; MATHEMATICAL-MODEL ; MICROCIRCULATION ; CIRRHOSIS ; FIBROSIS ; DISEASE
WOS ID: WOS:000406348600013
ISSN: 0567-7718
Funder: National Natural Science Foundation of China(31230027 ; Frontier Science Key Project of Chinese Science Academy(QYZDJ-SSW-JSC018) ; 91642203 ; 31661143044)
Department: NML分子-细胞生物力学与空间生命科学
Classification: 二类
Ranking: 1
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/60920
Appears in Collections:国家微重力实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
JouArt-2017-086.pdf(1617KB)期刊论文作者接受稿开放获取View Download

Recommended Citation:
Hu JR,Lv SQ,Feng, Shiliang,et al. Flow dynamics analyses of pathophysiological liver lobules using porous media theory[J]. ACTA MECHANICA SINICA,2017-08-01,33(4):823-832.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[胡锦荣]'s Articles
[吕守芹]'s Articles
[Feng, Shiliang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[胡锦荣]‘s Articles
[吕守芹]‘s Articles
[Feng, Shiliang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: JouArt-2017-086.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院力学研究所 - Feedback
Powered by CSpace