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Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles
Hu QL; Bai X(白轩); Hu GQ(胡国庆); Zuo YY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
Source PublicationACS NANO
2017-07-01
Volume11Issue:7Pages:6832-6842
ISSN1936-0851
Abstract

The growing risk of human exposure to airborne nanoparticles (NPs) causes a general concern on the biosafety of nanotechnology. Inhaled NPs can deposit in the deep lung at which they interact with the pulmonary surfactant (PS). Despite the increasing study of nano-bio interactions, detailed molecular mechanisms by which inhaled NPs interact with the natural PS system remain unclear. Using coarse-grained molecular dynamics simulation, we studied the interaction between NPs and the PS system in the alveolar fluid. It was found that regardless of different physicochemical properties, upon contacting the PS, both silver and polystyrene NPs are immediately coated with a biomolecular corona that consists of both lipids and proteins. Structure and molecular conformation of the PS corona depend on the hydrophobicity of the pristine NPs. Quantitative analysis revealed that lipid composition of the corona formed on different NPs is relatively conserved and is similar to that of the bulk phase PS. However, relative abundance of the surfactant-associated proteins, SP-A, SP-B, and SP-C, is notably affected by the hydrophobicity of the NP. The PS corona provides the NPs with a physicochemical barrier against the environment, equalizes the hydrophobicity of the pristine NPs, and may enhance biorecognition of the NPs. These modifications in physicochemical properties may play a crucial role in affecting the biological identity of the NPs and hence alter their subsequent interactions with cells and other biological entities. Our results suggest that all studies of inhalation nanotoxicology or NP-based pulmonary drug delivery should consider the influence of the PS corona.

KeywordPulmonary Surfactant Nanoparticle Biomolecular Corona Molecular Dynamics Nanotoxicology
DOI10.1021/acsnano.7b01873
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000406649700031
WOS KeywordProtein Corona ; Biophysical Properties ; Alveolar Macrophages ; Silver Nanoparticles ; Carbon Nanotubes ; Epithelial-cells ; Graphene Oxide ; Force-field ; Sp-a ; Lung
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNSFC(91543125 ; CAS Key Research Program of Frontier Sciences(QYZDB-SSW-JSC036) ; CAS Strategic Priority Research Program(XDB22040403) ; NSF(CBET-1604119 ; 11572334) ; CBET-1236596)
DepartmentLNM微纳米流体力学
Classification一类
Ranking1
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/70036
Collection非线性力学国家重点实验室
Corresponding AuthorZuo YY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu QL,Bai X,Hu GQ,et al. Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles[J]. ACS NANO,2017,11(7):6832-6842.
APA Hu QL,Bai X,Hu GQ,Zuo YY,&Hu, GQ .(2017).Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles.ACS NANO,11(7),6832-6842.
MLA Hu QL,et al."Unveiling the Molecular Structure of Pulmonary Surfactant Corona on Nanoparticles".ACS NANO 11.7(2017):6832-6842.
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