IMECH-IR  > 非线性力学国家重点实验室
Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets
Luo Z; Li SX; Xu Y; Ren H; Zhang XR; Hu GQ(胡国庆); Huang FY; Yue TT
Source PublicationENVIRONMENTAL SCIENCE-NANO
2018
Volume5Issue:1Pages:130-140
ISSN2051-8153
AbstractThe increasing risk of human exposure to emerging nanoparticles (NPs) has created a wide concern about their inhalation toxicity. Once NPs are inhaled, they get through the branching airway to deposit in the alveoli, where a thin pulmonary surfactant (PS) layer acts as the first barrier against them entering the deep lung. However, in terms of the inhalation toxicity of NPs, the mechanisms by which inhaled NPs interact with the PS layer and how the morphological change of NPs due to the PS layer interactions influences the subsequent fate of NPs are still elusive. By using molecular dynamics simulations, we investigate the interactions between graphene nanosheets (GNs) and the PS layer. It is found that when GNs suspend above or slowly penetrate the PS layer, PS molecules can spontaneously be extracted from the layer and made to form inverse micelles via cooperative molecular motion and rearrangement on the GN surfaces. We demonstrate that the PS layer tension and GN properties like size, oxidation ratio and curvature significantly affect the extraction dynamics. Notably, for curved GNs, only the concave surface can vigorously extract PS molecules, showing that the dispersive adhesion between GN and PS dominates the extracting and rearranging process. Our results propose new mechanisims for the experimental findings on the inhalation toxicity of graphene-family nanomaterials. Moreover, bearing in mind that the surface properties of GNs have been masked by adsorbed PS molecules, the newly formed structure may act like a corona that influences the biological identity of GNs. Therefore, anyone either evaluating inhalation toxicity or promoting biomedical applications of GNs should consider the first contact with PS at the air-water interface in alveoli.
DOI10.1039/c7en00843k
Indexed BySCI
Language英语
WOS IDWOS:000423017400011
WOS KeywordPROTEIN CORONA ; DRUG-DELIVERY ; CARBON NANOTUBES ; PHYSICOCHEMICAL PROPERTIES ; MOLECULAR-DYNAMICS ; LIPID MONOLAYER ; NANO-GRAPHENE ; NANOPARTICLES ; OXIDE ; TOXICITY
WOS Research AreaChemistry ; Environmental Sciences & Ecology ; Science & Technology - Other Topics
WOS SubjectChemistry, Multidisciplinary ; Environmental Sciences ; Nanoscience & Nanotechnology
Funding OrganizationNational Natural Science Foundation of China(21303269 ; Science and Technology Major Project of Shandong Province(2016GSF117033) ; Qingdao Science and Technology Project(16-5-1-73-jch) ; CAS(QYZDB-SSW-JSC036 ; LNM ; 91543125) ; XDB22040403)
Classification一类
Ranking5+
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/72247
Collection非线性力学国家重点实验室
Recommended Citation
GB/T 7714
Luo Z,Li SX,Xu Y,et al. Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets[J]. ENVIRONMENTAL SCIENCE-NANO,2018,5(1):130-140.
APA Luo Z.,Li SX.,Xu Y.,Ren H.,Zhang XR.,...&Yue TT.(2018).Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets.ENVIRONMENTAL SCIENCE-NANO,5(1),130-140.
MLA Luo Z,et al."Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets".ENVIRONMENTAL SCIENCE-NANO 5.1(2018):130-140.
Files in This Item: Download All
File Name/Size DocType Version Access License
Jp-2018-018.pdf(9040KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Luo Z]'s Articles
[Li SX]'s Articles
[Xu Y]'s Articles
Baidu academic
Similar articles in Baidu academic
[Luo Z]'s Articles
[Li SX]'s Articles
[Xu Y]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Luo Z]'s Articles
[Li SX]'s Articles
[Xu Y]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Jp-2018-018.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.