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Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs
Cui Y; Yao Y; Zhao YN; Xiao ZF; Cao ZF; Han SF; Li X; Huan Y(郇勇); Pan JL; Dai JW
发表期刊JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
2018-05-01
卷号12期号:5页码:1285-1296
ISSN1932-6254
摘要

Numerous studies have focused on the development of novel and innovative approaches for the treatment of peripheral nerve injury using artificial nerve guide conduits. In this study, we attempted to bridge 3.5-cm defects of the sciatic nerve with a longitudinally oriented collagen conduit (LOCC) loaded with human umbilical cord mesenchymal stem cells (hUC-MSCs). The LOCC contains a bundle of longitudinally aligned collagenous fibres enclosed in a hollow collagen tube. Our previous studies showed that an LOCC combined with neurotrophic factors enhances peripheral nerve regeneration. However, it remained unknown whether an LOCC seeded with hUC-MSCs could also promote regeneration. In this study, using various histological and electrophysiological analyses, we found that an LOCC provides mechanical support to newly growing nerves and functions as a structural scaffold for cells, thereby stimulating sciatic nerve regeneration. The LOCC and hUC-MSCs synergistically promoted regeneration and improved the functional recovery in a dog model of sciatic nerve injury. Therefore, the combined use of an LOCC and hUC-MSCs might have therapeutic potential for the treatment of peripheral nerve injury.

关键词Dog Human Umbilical Cord Mesenchymal Stem Cells (Huc-mscs) Longitudinally Oriented Collagen Conduit (Locc) Nerve Regeneration Sciatic Nerve
DOI10.1002/term.2660
收录类别SCI
语种英语
WOS记录号WOS:000432018500013
关键词[WOS]Peripheral-nerve ; Growth-factor ; Schwann-cells ; Bone-marrow ; Repair ; Scaffolds ; Injury ; Therapy ; System ; Rats
WOS研究方向Cell Biology ; Biotechnology & Applied Microbiology ; Engineering
WOS类目Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical
项目资助者Youth Innovation Promotion Association, CAS(2016096) ; National Key Research and Development Project(2016YFC1101500 ; Key Research Program of the Chinese Academy of Sciences(ZDRW-ZS-2016-2) ; 2016YFC1000800)
论文分区一类
力学所作者排名5+
引用统计
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/77474
专题非线性力学国家重点实验室
推荐引用方式
GB/T 7714
Cui Y,Yao Y,Zhao YN,et al. Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs[J]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,2018,12(5):1285-1296.
APA Cui Y.,Yao Y.,Zhao YN.,Xiao ZF.,Cao ZF.,...&Dai JW.(2018).Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs.JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE,12(5),1285-1296.
MLA Cui Y,et al."Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs".JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE 12.5(2018):1285-1296.
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