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Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis
Feng SL; Zhou LW(周吕文); Lv SQ(吕守芹); Zhang Y(章燕)
Source PublicationPHYSICAL BIOLOGY
2018-09-01
Volume15Issue:5
ISSN1478-3967
AbstractDirected movement of eukaryotic cells toward spatiotemporally varied chemotactic stimuli enables rapid intracellular signaling responses. While macroscopic cellular manifestation is shaped by balancing external stimuli strength with finite internal delays, the organizing principles of the underlying molecular mechanisms remain to be clarified. Here, we developed a novel modeling framework based on a simple seesaw mechanism to elucidate how cells repeatedly reverse polarity. As a key feature of the modeling, the bottom module of bidirectional molecular transport is successively controlled by three upstream modules of signal reception, initial signal processing, and Rho GTPase regulation. Our simulations indicated that an isotropic cell is polarized in response to a graded input signal. By applying a reversal gradient to a chemoattractant signal, lamellipod-specific molecules (i.e. PIP3 and PI3K) disappear, first from the cell front, and then they redistribute at the opposite side, whereas functional molecules at the rear of the cell (i.e. PIP2 and PTEN) act oppositely. In particular, the model cell exhibits a seesaw-like spatiotemporal pattern for the establishment of front and rear and interconversion, consistent with those related experimental observations. Increasing the switching frequency of the chemotactic gradient causes the cell to stay in a trapped state, further supporting the proposed dynamics of eukaryotic chemotaxis with the underlying cytoskeletal remodeling.
KeywordPolarization Signaling Cascade Mathematical Model Lattice-boltzmann Method
DOI10.1088/1478-3975/aac45b
Indexed BySCI
Language英语
WOS IDWOS:000433478400001
WOS KeywordREACTION-DIFFUSION SYSTEM ; CELL POLARITY ; NEUTROPHIL CHEMOTAXIS ; DICTYOSTELIUM CELLS ; RHO-GTPASES ; LOCAL-EXCITATION ; PTEN ; POLARIZATION ; MIGRATION ; MOTILITY
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
Funding OrganizationNational Natural Science Foundation of China(31230027 ; National Key Research and Development Program of China(2016YFA0501601) ; Strategic Priority Research Program(XDB22040101) ; Frontier Science Key Project(QYZDJ-SSWJSC018) ; 91539119 ; 11502272)
ClassificationQ3
Ranking1
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/77506
Collection国家微重力实验室
Recommended Citation
GB/T 7714
Feng SL,Zhou LW,Lv SQ,et al. Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis[J]. PHYSICAL BIOLOGY,2018,15(5).
APA Feng SL,周吕文,吕守芹,&章燕.(2018).Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis.PHYSICAL BIOLOGY,15(5).
MLA Feng SL,et al."Dynamic seesaw model for rapid signaling responses in eukaryotic chemotaxis".PHYSICAL BIOLOGY 15.5(2018).
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