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Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles
Wang JP1; Zhang LY2,3,4; Peng F1,5; Shi XH(施兴华)2,3,4; Leong DT1

Endothelial leakiness or permeability directly determines the access of any bionanotechnology to the target tissue site. Currently, cancer nanotechnology relies on tumor-derived endothelial leakiness, which suffers from unreliability, inhomogeneity of leakiness, and uncontrollability. Nanomaterials by themselves are capable of inducing endothelial leakiness (NanoEL) without any tumor involvement by targeting the endothelial cell junctions; this NanoEL phenomenon not well understood. Here, we showed that the negatively charged Au nanoparticles (NPs) induce significantly higher NanoEL than positively charged nanoparticles. We hypothesized and showed that in both in vitro and in silico models that cell junction targeting arose for the negatively charged particles due to a succession of repulsive-sedimentary interactions between the negative particle and the negatively charged glycocalyx found on the cell membrane surface. On the contrary, NPs with positive charges are attracted stably by the negatively charged glycocalyx and remained in situ for long enough, which eventually are endocytosized into the cells as contrasted to localization toward the cell junction. There are implications to how nanoparticle charges could be tuned to induce (or avoid) endothelial leakiness by design.

Indexed BySCI ; EI
WOS IDWOS:000435416600023
WOS KeywordSerum-albumin ; Ve-cadherin ; Stem-cells ; Cancer ; Glycocalyx ; Nanomaterials ; Permeability ; Particles ; Normalization ; Leakiness
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary
Funding OrganizationMinistry of Education Singapore Tier 2 Grant(MOE2013-T2-2-093) ; National Science Foundation China(11422215 ; 11672079)
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Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorShi XH(施兴华); Leong DT
Affiliation1.Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Natl Univ Singapore, Fac Sci, Dept Pharm, 18 Sci Dr 4, Singapore 117543, Singapore
Recommended Citation
GB/T 7714
Wang JP,Zhang LY,Peng F,et al. Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles[J]. CHEMISTRY OF MATERIALS,2018,30(11):3759-3767.
APA Wang JP,Zhang LY,Peng F,Shi XH,&Leong DT.(2018).Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles.CHEMISTRY OF MATERIALS,30(11),3759-3767.
MLA Wang JP,et al."Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles".CHEMISTRY OF MATERIALS 30.11(2018):3759-3767.
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