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Binding constant of cell adhesion receptors and substrate-immobilized ligands depends on the distribution of ligands
Li L(李龙); Hu JL; Xu GK; Song F(宋凡)
Source PublicationPHYSICAL REVIEW E
2018-01-16
Volume97Issue:1Pages:12405
ISSN2470-0045
AbstractCell-cell adhesion and the adhesion of cells to tissues and extracellular matrix, which are pivotal for immune response, tissue development, and cell locomotion, depend sensitively on the binding constant of receptor and ligand molecules anchored on the apposing surfaces. An important question remains of whether the immobilization of ligands affects the affinity of binding with cell adhesion receptors. We have investigated the adhesion of multicomponent membranes to a flat substrate coated with immobile ligands using Monte Carlo simulations of a statistical mesoscopic model with biologically relevant parameters. We find that the binding of the adhesion receptors to ligands immobilized on the substrate is strongly affected by the ligand distribution. In the case of ligand clusters, the receptor-ligand binding constant can be significantly enhanced due to the less translational entropy loss of lipid-raft domains in the model cell membranes upon the formation of additional complexes. For ligands randomly or uniformly immobilized on the substrate, the binding constant is rather decreased since the receptors localized in lipid-raft domains have to pay an energetic penalty in order to bind ligands. Our findings help to understand why cell-substrate adhesion experiments for measuring the impact of lipid rafts on the receptor-ligand interactions led to contradictory results.
DOI10.1103/PhysRevE.97.012405
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000423129500013
WOS KeywordMEMBRANE-ANCHORED RECEPTORS ; LIPID RAFTS ; PLASMA-MEMBRANE ; L-SELECTIN ; KINETICS ; TCR ; FLOW ; FLUCTUATIONS ; MIGRATION ; RESPONSES
WOS Research AreaPhysics, Fluids & Plasmas ; Physics, Mathematical
WOS SubjectPhysics
Funding OrganizationPrograms in the National Natural Science Foundation of China [11472285, 11232013, 21504038, 11402193] ; Strategic Priority Research Program of the Chinese Academy of Sciences [XDB22040102] ; National Key Research and Development Program of China [2016YFA0501601] ; Fundamental Research Funds for the Central Universities ; Shenzhen Science and Technology Innovation Committee [JCYJ20160531151105346]
Classification一类
Ranking1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/77792
Collection非线性力学国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Jiangsu, Peoples R China
4.Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China
5.Xi An Jiao Tong Univ, Sch Aerosp, Xian 710049, Shaanxi, Peoples R China
6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li L,Hu JL,Xu GK,et al. Binding constant of cell adhesion receptors and substrate-immobilized ligands depends on the distribution of ligands[J]. PHYSICAL REVIEW E,2018,97(1):12405.
APA 李龙,Hu JL,Xu GK,&宋凡.(2018).Binding constant of cell adhesion receptors and substrate-immobilized ligands depends on the distribution of ligands.PHYSICAL REVIEW E,97(1),12405.
MLA 李龙,et al."Binding constant of cell adhesion receptors and substrate-immobilized ligands depends on the distribution of ligands".PHYSICAL REVIEW E 97.1(2018):12405.
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