IMECH-IR  > 非线性力学国家重点实验室
Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant
Bai X(白轩); Xu M; Liu SJ; Hu GQ(胡国庆)
2018-06-20
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号10期号:24页码:20368-20376
ISSN1944-8244
摘要When inhaled nanoparticles (NPs) come into the deep lung, they develop a biomolecular corona by interacting with the pulmonary surfactant. The adsorption of the phospholipids and proteins gives a new biological identity to the NPs, which may alter their subsequent interactions with cells and other biological entities. Investigations of the interaction between the cell membrane and NPs coated with such a biomolecular corona are important in understanding the role of the biofluids on cellular uptake and estimating the dosing capacity and the nanotoxicology of NPs. In this paper, using dissipative particle dynamics, we investigate how the physicochemical properties of the coating pulmonary surfactant lipids and proteins affect the membrane response for inhaled NPs. We pinpoint several key factors in the endocytosis of lipid NPs, including the deformation of the coating lipids, coating lipid density, and ligand-receptor binding strength. Further studies reveal that the deformation of the coating lipids consumes energy but on the other hand promotes the coating ligands to bind with receptors more tightly. The coating lipid density controls the amount of the ligands as well as the hydrophobicity of the lipid NPs, thus affecting the endocytosis kinetics through the specific and nonspecific interactions. It is also found that the hydrophobic surfactant proteins associated with lipids can accelerate the endocytosis process of the NPs, but the endocytosis efficiency mainly depends on the density of the coating surfactant lipids. These findings can help understand how the pulmonary surfactant alters the biocompatibility of the inhaled NPs and provide some guidelines in designing an NP complex for efficient pulmonary drug delivery.
关键词endocytosis pulmonary surfactant nanoparticle corona dissipative particle dynamics simulation
DOI10.1021/acsami.8b06764
URL查看原文
收录类别SCI ; EI
语种英语
WOS记录号WOS:000436211500018
关键词[WOS]RECEPTOR-MEDIATED ENDOCYTOSIS ; WALLED CARBON NANOTUBES ; PROTEIN CORONA ; DRUG-DELIVERY ; PHYSICOCHEMICAL PROPERTIES ; MESOSCOPIC SIMULATION ; COMPUTER-SIMULATION ; EPITHELIAL-CELLS ; LUNG ; TRANSLOCATION
WOS研究方向Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS类目Science & Technology - Other Topics ; Materials Science
项目资助者NSFC [91543125, 11572334, 21425731, 21637004] ; CAS Key Research Program of Frontier Sciences [QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program [XDB22040403, XDB14000000] ; national "973" program [2014CB932000]
论文分区一类
力学所作者排名1
引用统计
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/77827
专题非线性力学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Bai X,Xu M,Liu SJ,et al. Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(24):20368-20376.
APA 白轩,Xu M,Liu SJ,&胡国庆.(2018).Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant.ACS APPLIED MATERIALS & INTERFACES,10(24),20368-20376.
MLA 白轩,et al."Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant".ACS APPLIED MATERIALS & INTERFACES 10.24(2018):20368-20376.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[白轩]的文章
[Xu M]的文章
[Liu SJ]的文章
百度学术
百度学术中相似的文章
[白轩]的文章
[Xu M]的文章
[Liu SJ]的文章
必应学术
必应学术中相似的文章
[白轩]的文章
[Xu M]的文章
[Liu SJ]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。