Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant

doi:10.1021/acsami.8b06764

IMECH-IR > 非线性力学国家重点实验室

	Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant
	Bai X(白轩); Xu M ; Liu SJ ; Hu GQ(胡国庆)
发表期刊	ACS APPLIED MATERIALS & INTERFACES
	2018-06-20
卷号	10 期号:24 页码:20368-20376
ISSN	1944-8244
摘要	When inhaled nanoparticles (NPs) come into the deep lung, they develop a biomolecular corona by interacting with the pulmonary surfactant. The adsorption of the phospholipids and proteins gives a new biological identity to the NPs, which may alter their subsequent interactions with cells and other biological entities. Investigations of the interaction between the cell membrane and NPs coated with such a biomolecular corona are important in understanding the role of the biofluids on cellular uptake and estimating the dosing capacity and the nanotoxicology of NPs. In this paper, using dissipative particle dynamics, we investigate how the physicochemical properties of the coating pulmonary surfactant lipids and proteins affect the membrane response for inhaled NPs. We pinpoint several key factors in the endocytosis of lipid NPs, including the deformation of the coating lipids, coating lipid density, and ligand-receptor binding strength. Further studies reveal that the deformation of the coating lipids consumes energy but on the other hand promotes the coating ligands to bind with receptors more tightly. The coating lipid density controls the amount of the ligands as well as the hydrophobicity of the lipid NPs, thus affecting the endocytosis kinetics through the specific and nonspecific interactions. It is also found that the hydrophobic surfactant proteins associated with lipids can accelerate the endocytosis process of the NPs, but the endocytosis efficiency mainly depends on the density of the coating surfactant lipids. These findings can help understand how the pulmonary surfactant alters the biocompatibility of the inhaled NPs and provide some guidelines in designing an NP complex for efficient pulmonary drug delivery.
关键词	endocytosis pulmonary surfactant nanoparticle corona dissipative particle dynamics simulation
DOI	10.1021/acsami.8b06764
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000436211500018
关键词[WOS]	RECEPTOR-MEDIATED ENDOCYTOSIS ; WALLED CARBON NANOTUBES ; PROTEIN CORONA ; DRUG-DELIVERY ; PHYSICOCHEMICAL PROPERTIES ; MESOSCOPIC SIMULATION ; COMPUTER-SIMULATION ; EPITHELIAL-CELLS ; LUNG ; TRANSLOCATION
WOS研究方向	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS类目	Science & Technology - Other Topics ; Materials Science
项目资助者	NSFC [91543125, 11572334, 21425731, 21637004] ; CAS Key Research Program of Frontier Sciences [QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program [XDB22040403, XDB14000000] ; national "973" program [2014CB932000]
论文分区	一类
力学所作者排名	1
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/77827
专题	非线性力学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bai X,Xu M,Liu SJ,et al. Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10,24,:20368-20376.
APA	白轩,Xu M,Liu SJ,&胡国庆.(2018).Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant.ACS APPLIED MATERIALS & INTERFACES,10(24),20368-20376.
MLA	白轩,et al."Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant".ACS APPLIED MATERIALS & INTERFACES 10.24(2018):20368-20376.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
IrJ2018212.pdf（4170KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载