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Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector
Zhou LW(周吕文); Zhang C(张晨); Zhang F(张芳); Lv SQ(吕守芹); Sun SJ(孙树津); Lv DY(吕东媛); Long M(龙勉)
2018-02-01
发表期刊BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
卷号17期号:1页码:191-203
ISSN1617-7959
摘要Translocation of dense nucleus along gravity vector initiates mechanical remodeling of a eukaryotic cell. In our previous experiments, we quantified the impact of gravity vector on cell remodeling by placing an MC3T3-E1 cell onto upward (U)-, downward (D)-, or edge-on (E)- orientated substrate. Our experimental data demonstrate that orientation dependence of nucleus longitudinal translocation is positively correlated with cytoskeletal (CSK) remodeling of their expressions and structures and also is associated with rearrangement of focal adhesion complex (FAC). However, the underlying mechanism how CSK network and FACs are reorganized in a mammalian cell remains unclear. In this paper, we developed a theoretical biomechanical model to integrate the mechanosensing of nucleus translocation with CSK remodeling and FAC reorganization induced by a gravity vector. The cell was simplified as a nucleated tensegrity structure in the model. The cell and CSK filaments were considered to be symmetrical. All elements of CSK filaments and cytomembrane that support the nucleus were simplified as springs. FACs were simplified as an adhesion cluster of parallel bonds with shared force. Our model proposed that gravity vector-directed translocation of the cell nucleus is mechanically balanced by CSK remodeling and FAC reorganization induced by a gravitational force. Under gravity, dense nucleus tends to translocate and exert additional compressive or stretching force on the cytoskeleton. Finally, changes of the tension force acting on talin by microfilament alter the size of FACs. Results from our model are in qualitative agreement with those from experiments.
关键词Gravity directed Mechanosensing Nucleus translocation Cytoskeletal remodeling FAC reorganization
DOI10.1007/s10237-017-0954-y
URL查看原文
收录类别SCI ; EI
语种英语
WOS记录号WOS:000424651600014
关键词[WOS]INTERMEDIATE-FILAMENTS ; FOCAL ADHESIONS ; ADHERENT CELLS ; CYTOSKELETON ; MECHANOTRANSDUCTION ; MICROGRAVITY ; ARCHITECTURE ; FORCE
WOS研究方向Biophysics ; Engineering, Biomedical
WOS类目Biophysics ; Engineering
项目资助者Strategic Priority Research Program of Chinese Science Academy of Sciences [XDA04020219] ; National Natural Science Foundation of China [31110103918] ; National Key Basic Research Foundation of China [2011CB710904]
论文分区二类
力学所作者排名1
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文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/77879
专题国家微重力实验室
作者单位1.Chinese Acad Sci, Ctr Biomech & Bioengn, Lab Micrograv, Natl Micrograv Lab, Beijing, Peoples R China
2.Chinese Acad Sci, Beijing Key Lab Engn Construct & Mech, Inst Mech, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
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Zhou LW,Zhang C,Zhang F,et al. Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector[J]. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY,2018,17(1):191-203.
APA 周吕文.,张晨.,张芳.,吕守芹.,孙树津.,...&龙勉.(2018).Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector.BIOMECHANICS AND MODELING IN MECHANOBIOLOGY,17(1),191-203.
MLA 周吕文,et al."Theoretical modeling of mechanical homeostasis of a mammalian cell under gravity-directed vector".BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 17.1(2018):191-203.
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