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Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy
Liu YJ; Chen XD(陈晓东); Guo AY; Liu SJ; Hu GQ(胡国庆)
Source PublicationADVANCED SCIENCE
AbstractAlthough radial extracorporeal shock wave therapy (rESWT) has been widely used to treat orthopedic disorders with promising clinical results, rESWT largely relies on clinicians' personal experiences and arbitrary judgments, without knowing relationships between administration doses and effective doses at target sites. In fact, practitioners lack a general and reliable way to assess propagation and distribution of pressure waves inside biological tissues quantitatively. This study develops a methodology to combine experimental measurements and computational simulations to obtain pressure fields from rESWT through calibrating and validating computational models with experimental measurements. Wave pressures at the bottom of a petri dish and inside biological tissues are measured, respectively, by attaching and implanting flexible membrane sensors. Detailed wave dynamics are simulated through explicit finite element analyses. The data decipher that waves from rESWT radiate directionally and can be modeled as acoustic waves generated from a vibrating circular piston. Models are thus established to correlate pressure amplitudes at the bottom of petri dishes and in the axial direction of biological tissues. Additionally, a pilot simulation upon rESWT for human lumbar reveals a detailed and realistic pressure field mapping. This study will open a new avenue of personalized treatment planning and mechanism research for rESWT.
Keywordexperimental measurements explicit dynamics analysis extracorporeal shock wave therapy finite element models
Indexed BySCI ; EI
WOS IDWOS:000428310500022
WOS Research AreaChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science
Funding OrganizationNational Natural Science Foundation of China [11402274, 11772343] ; CAS Key Research Program of Frontier Sciences [QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program [XDB22040403] ; Beijing Science and Technology Plan [Z171100000417025] ; Beijing Nova Program Interdisciplinary Studies Cooperative Projects
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Beijing Jishuitan Hosp, Orthoped Shock Wave Treatment Ctr, Spine Surg Dept, Beijing 100035, Peoples R China
2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
Recommended Citation
GB/T 7714
Liu YJ,Chen XD,Guo AY,et al. Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy[J]. ADVANCED SCIENCE,2018,5(3):1700797.
APA Liu YJ,陈晓东,Guo AY,Liu SJ,&胡国庆.(2018).Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy.ADVANCED SCIENCE,5(3),1700797.
MLA Liu YJ,et al."Quantitative Assessments of Mechanical Responses upon Radial Extracorporeal Shock Wave Therapy".ADVANCED SCIENCE 5.3(2018):1700797.
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