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Diffusion of rod-like nanoparticles in non-adhesive and adhesive porous polymeric gels
Wang JL; Yang YW; Yu MR; Hu GQ(胡国庆); Gan Y; Gao HJ; Shi XH(施兴华)
Source PublicationJOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
2018-03-01
Volume112Pages:431-457
ISSN0022-5096
AbstractIt is known that rod-like nanoparticles (NPs) can achieve higher diffusivity than their spherical counterparts in biological porous media such as mucus and tumor interstitial matrix, but the underlying mechanisms still remain elusive. Here, we present a joint experimental and theoretical study to show that the aspect ratio (AR) of NPs and their adhesive interactions with the host medium play key roles in such anomalous diffusion behaviors of nanorods. In an adhesive polymer solution/gel (e.g., mucus), hopping diffusion enables nanorods to achieve higher diffusivity than spherical NPs with diameters equal to the minor axis of the rods, and there exists an optimal AR that leads to maximum diffusivity. In contrast, the diffusivity of nanorods decreases monotonically with increasing AR in a non-adhesive polymer solution/gel (e.g., hydroxyethyl cellulose, HEC). Our theoretical model, which captures all the experimental observations, generalizes the so-called obstruction scaling model by incorporating the effects of the NPs/matrix interaction via the mean first passage time (MFPT) theory. This work reveals the physical origin of the anomalous diffusion behaviors of rod-like NPs in biological gels and may provide guidelines for a range of applications that involve NPs diffusion in complex porous media. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordNanoparticle diffusion Shape effect Mucus Nanorods Porous media Mean first passage time
DOI10.1016/j.jmps.2017.12.014
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000426536400024
WOS KeywordOBSTRUCTION-SCALING MODEL ; ANOMALOUS DIFFUSION ; SOLUTE DIFFUSION ; RAPID-TRANSPORT ; BROWNIAN-MOTION ; MONTE-CARLO ; HUMAN MUCUS ; IN-VIVO ; MECHANISMS ; PARTICLES
WOS Research AreaMaterials Science, Multidisciplinary ; Mechanics ; Physics, Condensed Matter
WOS SubjectMaterials Science ; Mechanics ; Physics
Funding OrganizationNational Natural Science Foundation of China [11422215, 11272327, 11672079, 81373356, 81573378, 8177130638] ; "Science and technology innovation action plan for basic research" of Shanghai [14JC1493200] ; National Science Foundation [CMMI-1562904] ; Opening fund of State Key Laboratory of Nonlinear Mechanics ; Supercomputing Center of Chinese Academy of Sciences (SCCAS) ; [CASIMM0120153020]
Classification一类/力学重要期刊
Ranking4
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/77919
Collection非线性力学国家重点实验室
Affiliation1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
5.Brown Univ, Sch Engn, Providence, RI 02912 USA
Recommended Citation
GB/T 7714
Wang JL,Yang YW,Yu MR,et al. Diffusion of rod-like nanoparticles in non-adhesive and adhesive porous polymeric gels[J]. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,2018,112:431-457.
APA Wang JL.,Yang YW.,Yu MR.,胡国庆.,Gan Y.,...&施兴华.(2018).Diffusion of rod-like nanoparticles in non-adhesive and adhesive porous polymeric gels.JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,112,431-457.
MLA Wang JL,et al."Diffusion of rod-like nanoparticles in non-adhesive and adhesive porous polymeric gels".JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS 112(2018):431-457.
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