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Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model
Tang H; Jia WS; Hou XL; Zhao YN; Huan Y(郇勇); Chen W; Yu W; Zhu MMO; Ye G; Chen B; Dai JW
Source PublicationBIOMEDICAL MATERIALS
2018-05-01
Volume13Issue:3Pages:31001
ISSN1748-6041
AbstractRegeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction.
Keywordcollagen basic fibroblast growth factor collagen-binding domain corpus spongiosum urethral regeneration
DOI10.1088/1748-605X/aa9f01
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000425739900001
WOS KeywordFIBROBLAST-GROWTH-FACTOR ; URETHRAL RECONSTRUCTION ; STEM-CELLS ; RABBIT MODEL ; BINDING BFGF ; DEFECTS ; INJURY ; RATS ; URETHROPLASTY ; IMPROVES
WOS Research AreaEngineering, Biomedical ; Materials Science, Biomaterials
WOS SubjectEngineering ; Materials Science
Funding OrganizationNational Key R&D Program of China [2016YFC1000807, 2016YFC1000800, 2016YFC1000801, 2016YFC1000802]
Classification二类
Ranking5
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/77924
Collection非线性力学国家重点实验室
Affiliation1.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Dept Chem Def Med, Chongqing 400038, Peoples R China
2.Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Urol,Ctr Nephrol, Chongqing 400037, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
5.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Cadet 17 Battal, Chongqing 400038, Peoples R China
6.Third Mil Med Univ, Army Med Univ, Coll Prevent Med,Chongqing Engn Res Ctr Nanomed, Inst Combined Injury,State Key Lab Trauma Burns &, Chongqing 400038, Peoples R China
Recommended Citation
GB/T 7714
Tang H,Jia WS,Hou XL,et al. Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model[J]. BIOMEDICAL MATERIALS,2018,13(3):31001.
APA Tang H.,Jia WS.,Hou XL.,Zhao YN.,Huan Y.,...&Dai JW.(2018).Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model.BIOMEDICAL MATERIALS,13(3),31001.
MLA Tang H,et al."Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model".BIOMEDICAL MATERIALS 13.3(2018):31001.
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