Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model

doi:10.1088/1748-605X/aa9f01

IMECH-IR > 非线性力学国家重点实验室

	Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model
	Tang H ; Jia WS ; Hou XL; Zhao YN ; Huan Y(郇勇); Chen W ; Yu W ; Zhu MMO ; Ye G ; Chen B ; Dai JW
发表期刊	BIOMEDICAL MATERIALS
	2018-05-01
卷号	13 期号:3 页码:31001
ISSN	1748-6041
摘要	Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction.
关键词	collagen basic fibroblast growth factor collagen-binding domain corpus spongiosum urethral regeneration
DOI	10.1088/1748-605X/aa9f01
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000425739900001
关键词[WOS]	FIBROBLAST-GROWTH-FACTOR ; URETHRAL RECONSTRUCTION ; STEM-CELLS ; RABBIT MODEL ; BINDING BFGF ; DEFECTS ; INJURY ; RATS ; URETHROPLASTY ; IMPROVES
WOS研究方向	Engineering, Biomedical ; Materials Science, Biomaterials
WOS类目	Engineering ; Materials Science
项目资助者	National Key R&D Program of China [2016YFC1000807, 2016YFC1000800, 2016YFC1000801, 2016YFC1000802]
论文分区	二类
力学所作者排名	5
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/77924
专题	非线性力学国家重点实验室
作者单位	1.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Dept Chem Def Med, Chongqing 400038, Peoples R China 2.Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Urol,Ctr Nephrol, Chongqing 400037, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China 5.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Cadet 17 Battal, Chongqing 400038, Peoples R China 6.Third Mil Med Univ, Army Med Univ, Coll Prevent Med,Chongqing Engn Res Ctr Nanomed, Inst Combined Injury,State Key Lab Trauma Burns &, Chongqing 400038, Peoples R China
推荐引用方式 GB/T 7714	Tang H,Jia WS,Hou XL,et al. Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model[J]. BIOMEDICAL MATERIALS,2018,13,3,:31001.
APA	Tang H.,Jia WS.,Hou XL.,Zhao YN.,Huan Y.,...&Dai JW.(2018).Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model.BIOMEDICAL MATERIALS,13(3),31001.
MLA	Tang H,et al."Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model".BIOMEDICAL MATERIALS 13.3(2018):31001.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
IrJ2018312.pdf（4074KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载