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Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study
Cui XY; Ren QS(任庆帅); Li ZH; Peng K; Li GY; Gu ZY; Qiao AK
Source PublicationCMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
2018-09-01
Volume116Issue:3Pages:455-469
ISSN1526-1492
AbstractClinical application of bare metal stents is constrained by the occurrence of instent restenosis, mainly due to the complex biomechanical environment in the body. Numerical simulation method was used to evaluate the effect of plaque composition on stent performance in a carotid artery. CT angiography (CTA) data were used as a reference, and zero-load state of the carotid artery was used to establish a 3D stenotic artery model. Different plaque compositions, calcified and hypo-cellular were defined in Model 1 and Model 2, respectively. Interactions between the stents and arterial tissues within the stent crimping-expansion process were analyzed to explore the effects of plaque composition on the mechanical parameters of carotid stents. Goodman diagram and fatigue safety factor (FSF) were analyzed to explore the effects of plaque composition on fatigue performance of a carotid stent in the stent service process. In the stent crimping-expansion process, the von Mises stress in the stent and the dog-boning ratio in Model 1 were higher than that in Model 2. The calcified plaque prevented the stent from expanding the stenotic vessel to a pre-set diameter. Thus, the risk of rupture in the calcified plaque was higher than that in the hypo-cellular plaque. Plaque also affected the stress/strain in the vessel wall, which was observed to be lower in Model 1 than in Model 2. This indicated that calcified plaque could decrease the stress-induced injury of arterial tissues. Within the stent service process, the stents used in these two models were predicted to not fail under fatigue rupture as calculated by the Goodman diagram. Additionally, the points closer to the fatigue limit were generally observed at the inner bend of the stent crowns. The FSF of the stent in Model 1 was lower than that in Model 2. The stent operating in the presence of calcified plaques suffered high risk of fractures. Reliability and fatigue performance of the stent were found to be associated with plaque composition. Hence, this study may provide stent designers an approach toward enhancing the mechanical reliability of a stent.
KeywordPlaque composition biomechanical carotid stent
DOI10.31614/cmes.2018.04135
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000447242900007
WOS KeywordFATIGUE LIFE ANALYSIS ; ATHEROSCLEROTIC PLAQUES ; CORONARY STENT ; FSI MODELS ; FRACTURE ; ARTERY ; CALCIFICATION ; ANGIOPLASTY ; RESTENOSIS ; MECHANICS
WOS Research AreaEngineering, Multidisciplinary ; Mathematics, Interdisciplinary Applications
WOS SubjectEngineering ; Mathematics
Funding OrganizationMajor Project of Science and Technology of Beijing Municipal Education Commission ; Type B Project of Beijing Natural Science Foundation [KZ201710005007]
ClassificationQ4
Ranking2
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/78154
Collection职能与支撑部门
Affiliation1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100022, Peoples R China
2.Chinese Acad Sci, Inst Mech, 15 BeiSiHuanWest Rd, Beijing 100190, Peoples R China
3.Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi, Japan
Recommended Citation
GB/T 7714
Cui XY,Ren QS,Li ZH,et al. Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study[J]. CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,2018,116(3):455-469.
APA Cui XY.,任庆帅.,Li ZH.,Peng K.,Li GY.,...&Qiao AK.(2018).Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study.CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,116(3),455-469.
MLA Cui XY,et al."Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study".CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES 116.3(2018):455-469.
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