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Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study
Cui XY; Ren QS(任庆帅); Li ZH; Peng K; Li GY; Gu ZY; Qiao AK
发表期刊CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
2018-09-01
卷号116期号:3页码:455-469
ISSN1526-1492
摘要Clinical application of bare metal stents is constrained by the occurrence of instent restenosis, mainly due to the complex biomechanical environment in the body. Numerical simulation method was used to evaluate the effect of plaque composition on stent performance in a carotid artery. CT angiography (CTA) data were used as a reference, and zero-load state of the carotid artery was used to establish a 3D stenotic artery model. Different plaque compositions, calcified and hypo-cellular were defined in Model 1 and Model 2, respectively. Interactions between the stents and arterial tissues within the stent crimping-expansion process were analyzed to explore the effects of plaque composition on the mechanical parameters of carotid stents. Goodman diagram and fatigue safety factor (FSF) were analyzed to explore the effects of plaque composition on fatigue performance of a carotid stent in the stent service process. In the stent crimping-expansion process, the von Mises stress in the stent and the dog-boning ratio in Model 1 were higher than that in Model 2. The calcified plaque prevented the stent from expanding the stenotic vessel to a pre-set diameter. Thus, the risk of rupture in the calcified plaque was higher than that in the hypo-cellular plaque. Plaque also affected the stress/strain in the vessel wall, which was observed to be lower in Model 1 than in Model 2. This indicated that calcified plaque could decrease the stress-induced injury of arterial tissues. Within the stent service process, the stents used in these two models were predicted to not fail under fatigue rupture as calculated by the Goodman diagram. Additionally, the points closer to the fatigue limit were generally observed at the inner bend of the stent crowns. The FSF of the stent in Model 1 was lower than that in Model 2. The stent operating in the presence of calcified plaques suffered high risk of fractures. Reliability and fatigue performance of the stent were found to be associated with plaque composition. Hence, this study may provide stent designers an approach toward enhancing the mechanical reliability of a stent.
关键词Plaque composition biomechanical carotid stent
DOI10.31614/cmes.2018.04135
URL查看原文
收录类别SCI ; EI
语种英语
WOS记录号WOS:000447242900007
关键词[WOS]FATIGUE LIFE ANALYSIS ; ATHEROSCLEROTIC PLAQUES ; CORONARY STENT ; FSI MODELS ; FRACTURE ; ARTERY ; CALCIFICATION ; ANGIOPLASTY ; RESTENOSIS ; MECHANICS
WOS研究方向Engineering, Multidisciplinary ; Mathematics, Interdisciplinary Applications
WOS类目Engineering ; Mathematics
项目资助者Major Project of Science and Technology of Beijing Municipal Education Commission ; Type B Project of Beijing Natural Science Foundation [KZ201710005007]
论文分区Q4
力学所作者排名2
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文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/78154
专题职能与支撑部门
作者单位1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100022, Peoples R China
2.Chinese Acad Sci, Inst Mech, 15 BeiSiHuanWest Rd, Beijing 100190, Peoples R China
3.Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi, Japan
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Cui XY,Ren QS,Li ZH,et al. Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study[J]. CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,2018,116(3):455-469.
APA Cui XY.,任庆帅.,Li ZH.,Peng K.,Li GY.,...&Qiao AK.(2018).Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study.CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,116(3),455-469.
MLA Cui XY,et al."Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study".CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES 116.3(2018):455-469.
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