Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface

doi:10.1021/acs.nanolett.8b02638

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	Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface
	Wang XY ; Wang XF ; Bai X(白轩); Yan L; Liu T ; Wang MZ ; Song YT ; Hu GQ(胡国庆); Gu ZJ ; Miao Q(苗青); Chen CY
发表期刊	NANO LETTERS
	2019
卷号	19 期号:1 页码:8-18
ISSN	1530-6984
摘要	The nanoparticle (nano)-cell membrane interface is one of the most important interactions determining the fate of nanoparticles (NPs So far, there remains a lack of knowledge about the mechanisms governing the nanoparticle-cell membrane interface, especially the impact of ligand exchange, in which molecules on the nanosurface become replaced with components of the cell membrane, resulting in unique interfacial phenomena. Herein, we describe a family of gold nanoparticles (AuNPs) of the same core size (similar to 13 nm core The ligands are categorized according to their molecular weight, charge, and bonding modes (physisorption or chemisorption). Importantly, we found that, depending on the adsorption affinity and size of ligand molecules, physisorbed ligands on the surface of NPs can be exchanged with lipid molecules. At a ligand exchange-dominated interface, the AuNPs typically aggregated into an ordered monolayer in the lipid bilayers, subsequently affecting cell membrane integrity, NP uptake efficiency, and the NP endocytosis pathways. These findings advance our understanding of the underlying mechanisms of the biological effects of nanoparticles from a new point of view and will aid in the design of novel, safe, and effective nanomaterials for biomedicine.
关键词	Nanoparticles surface ligand exchange nanoparticle-cell membrane interface nanoparticle-biological effects molecular dynamics simulation
DOI	10.1021/acs.nanolett.8b02638
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000455561300002
关键词[WOS]	GOLD NANOPARTICLES ; SERUM-ALBUMIN ; DNA BASES ; CITRATE ; CORONA ; DESORPTION ; FORCES ; CYTOTOXICITY ; PENETRATION ; ADSORPTION
WOS研究方向	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS类目	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
项目资助者	National Basic Research Program of China from the Ministry of Science and Technology [2016YFA0201600, 2016YFE0133100] ; National Natural Science Foundation of China [91543125, 31571025, 21320102003, 11435002] ; Innovative Research Groups of the National Natural Science Foundation of China [11621505] ; National Science Fund for Distinguished Young Scholars [11425520]
论文分区	一类
力学所作者排名	3
引用统计	被引频次：76[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/78256
专题	非线性力学国家重点实验室
作者单位	1.Natl Ctr Nanoscienceand Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Natl Ctr Nanoscienceand Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 4.Shenyang Agr Univ, Coll Sci, Shenyang 110161, Liaoning, Peoples R China 5.Liaoning Univ, Coll Environm, Shenyang 110036, Liaoning, Peoples R China 6.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang XY,Wang XF,Bai X,et al. Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface[J]. NANO LETTERS,2019,19,1,:8-18.
APA	Wang XY.,Wang XF.,白轩.,Yan L.,Liu T.,...&Chen CY.(2019).Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface.NANO LETTERS,19(1),8-18.
MLA	Wang XY,et al."Nanoparticle Ligand Exchange and Its Effects at the Nanoparticle-Cell Membrane Interface".NANO LETTERS 19.1(2019):8-18.

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