Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging

doi:10.1021/acsnano.8b05136

IMECH-IR > 非线性力学国家重点实验室

	Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging
	Li XL ; Bottini M ; Zhang LY ; Zhang S ; Chen J ; Zhang TB ; Liu L ; Rosato N ; Ma XB ; Shi XH(施兴华); Wu Y ; Guo WS ; Liang XJ
发表期刊	ACS NANO
	2019
卷号	13 期号:1 页码:176-186
ISSN	1936-0851
摘要	It remains an unresolved challenge to achieve spatial and temporal monitoring of drug release from nano medicines (NMs) in vivo, which is of crucial importance in disease treatment. To tackle this issue, we constructed core-satellite ICG/DOX@Gel-CuS NMs, which consist of gelatin (Gel) nanoparticles (NPs) with payloads of near-infrared fluorochrome indocyanine green (ICG) and chemo-drug doxorubicin (DOX) and surrounding CuS NPs. The fluorescence of ICG was initially shielded by satellite CuS NPs within the intact ICG/DOX@Gel-CuS NMs and increased in proportion to the amount of DOX released from NMs in response to enzyme-activated NMs degradation. For more comprehensive understanding of the drug-release profile, a theoretical model derived from computer simulation was employed to reconstruct the enzyme-activatable drug release of the ICG/DOX@Gel-CuS NMs, which demonstrated the underlying kinetics functional relationship between the released DOX amount and recovered ICG fluorescence intensity. The kinetics of drug release in vivo was assessed by administrating ICG/DOX@Gel-CuS NMs both locally and systemically into MDA-MB-231 tumor-bearing mice. Upon accumulation of ICG/DOX@Gel-CuS NMs in the tumor, overexpressed enzymes triggered the degradation of the gelatin scaffold as well as the release of DOX and ICG, which can be visually depicted with the ICG fluorescence signal increasing only in the tumor area by fluorescence imaging. Additionally, the photoacoustic signal from CuS NPs was independent from the physical status of ICG/DOX@Gel-CuS NMs and hence was utilized for real-time NMs tracking. Thus, by taking advantage of the core satellite architecture and NMs degradability in tumor site, the DOX release profile of ICG/DOX@Gel-CuS NMs was monitored by fluorescence and photoacoustic dual-modal imaging in a real-time noninvasive manner.
关键词	core-satellite drug release in vivo nanomedicines computer simulation dual-modal imaging
DOI	10.1021/acsnano.8b05136
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000456749900019
关键词[WOS]	ENHANCED PERMEABILITY ; MAGNETIC-RESONANCE ; POLYMERIC MICELLES ; SOLUTE DIFFUSION ; NANOPARTICLES ; DELIVERY ; MECHANISMS ; HYDROGELS ; GELATIN ; LESSONS
WOS研究方向	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS类目	Chemistry ; Science & Technology - Other Topics ; Materials Science
项目资助者	National Natural Science Foundation Key Projects [31630027, 31430031, 81601603, 81773185, 81471739] ; NSFC-DFG project [31761133013] ; National Distinguished Young Scholars grant [31225009] ; external cooperation program of the Chinese Academy of Science [121D11KYSB20160066] ; "Strategic Priority Research Program" of the Chinese Academy of Sciences [XDA09030301] ; National Key Research Program of China [2016YFA0100900, 2016YFA0100902] ; NanOArt grant of the "Mission Sustain ability" of the University of Rome Tor Vergata
论文分区	一类
力学所作者排名	3
RpAuthor	Wu, Y ; Liang, XJ ; Guo, WS
引用统计	被引频次：59[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/78468
专题	非线性力学国家重点实验室
作者单位	1.{Li, XL、Bottini, M、Chen, J、Zhang, TB、Liu, L、Wu, Y、Liang, XJie} Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 First North Rd, Beijing 100190, Peoples R China 2.{Li, Xianlei、Liu, Lu、Ma, Xibo、Shi, Xinghua、Wu, Yan、Liang, Xing-Jie} Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.{Guo, Weisheng} Guangzhou Med Univ, Affiliated Hosp 2, Translat Med Ctr, State Key Lab Resp Dis, Guangzhou 510260, Guangdong, Peoples R China 4.{Bottini, Massimo、Rosato, Nicola} Univ Roma Tor Vergata, Dept Expt Med & Surg, Via Montpellier 1, I-00133 Rome, Italy 5.{Shi, Xinghua} Chinese Acad Sci, Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China 6.{Zhang, Luyao} Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China 7.{Zhang, Shuai、Ma, Xibo} Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li XL,Bottini M,Zhang LY,et al. Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging[J]. ACS NANO,2019,13,1,:176-186.
APA	Li XL.,Bottini M.,Zhang LY.,Zhang S.,Chen J.,...&Liang XJ.(2019).Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging.ACS NANO,13(1),176-186.
MLA	Li XL,et al."Core-Satellite Nanomedicines for in Vivo Real-Time Monitoring of Enzyme-Activatable Drug Release by Fluorescence and Photoacoustic Dual-Modal Imaging".ACS NANO 13.1(2019):176-186.

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