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Directional and Rotational Motions of Nanoparticles on Plasma Membranes as Local Probes of Surface Tension Propagation
Li SX; Yan ZS; Luo Z; Xu Y; Huang F; Hu GQ(胡国庆); Zhang XR; Yue TT
Corresponding AuthorHu, Guoqing(guoqing.hu@imech.ac.cn) ; Yue, Tongtao(yuett@upc.edu.cn)
Source PublicationLANGMUIR
2019-04-16
Volume35Issue:15Pages:5333-5341
ISSN0743-7463
AbstractMechanical heterogeneity is ubiquitous in plasma membranes and of essential importance to cellular functioning. As a feedback of mechanical stimuli, local surface tension can be readily changed and immediately propagated through the membrane, influencing structures and dynamics of both inclusions and membrane-associated proteins. Using the nonequilibrium coarse-grained membrane simulation, here we investigate the inter-related processes of tension propagation, lipid diffusion, and transport of nanoparticles (NPs) adhering on the membrane of constant tension gradient, mimicking that of migrating cells or cells under prolonged stimulation. Our results demonstrate that the lipid bilayer membrane can by itself propagate surface tension in defined rates and pathways to reach a dynamic equilibrium state where surface tension is linearly distributed along the gradient maintained by the directional flow-like motion of lipids. Such lipid flow exerts shearing forces to transport adhesive NPs toward the region of a larger surface tension. Under certain conditions, the shearing force can generate nonzero torques driving the rotational motion of NPs, with the direction of the NP rotation determined by the NP-membrane interaction state as functions of both NP property and local membrane surface tension. Such features endow NPs with promising applications ranging from biosensing to targeted drug delivery.
DOI10.1021/acs.langmuir.9b00225
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000465190000026
WOS KeywordRECEPTOR-MEDIATED ENDOCYTOSIS ; LATERAL DIFFUSION ; BILAYER-MEMBRANES ; LIPID-BILAYERS ; DRUG-DELIVERY ; DYNAMICS ; PARTICLE ; LIQUID ; SHAPE ; VESICULATION
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
Funding ProjectNational Natural Science Foundation of China[3 1871 012] ; National Natural Science Foundation of China[21303269] ; National Natural Science Foundation of China[11832017] ; National Natural Science Foundation of China[91543125] ; Natural Science Foundation of Shandong Province[ZR2018MC004]
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Shandong Province
Classification二类
Ranking5+
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79170
Collection非线性力学国家重点实验室
Recommended Citation
GB/T 7714
Li SX,Yan ZS,Luo Z,et al. Directional and Rotational Motions of Nanoparticles on Plasma Membranes as Local Probes of Surface Tension Propagation[J]. LANGMUIR,2019,35(15):5333-5341.
APA Li SX.,Yan ZS.,Luo Z.,Xu Y.,Huang F.,...&Yue TT.(2019).Directional and Rotational Motions of Nanoparticles on Plasma Membranes as Local Probes of Surface Tension Propagation.LANGMUIR,35(15),5333-5341.
MLA Li SX,et al."Directional and Rotational Motions of Nanoparticles on Plasma Membranes as Local Probes of Surface Tension Propagation".LANGMUIR 35.15(2019):5333-5341.
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