Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing | |
Wang ZL; Xianyu YL; Liu W(刘巍); Li YK; Cai ZX; Fu X; Jin G(靳刚); Niu Y(牛宇); Qi C; Chen YP | |
发表期刊 | ANALYTICAL CHEMISTRY |
2019-05-21 | |
卷号 | 91期号:10页码:6769-6774 |
ISSN | 0003-2700 |
摘要 | The main issues of imaging ellipsometry-based biosensing for small molecules are the low sensitivity and narrow detection range due to the low molecular weight of small molecules that results in a negligible signal. To meet this challenge, we theoretically investigated the deciding factors of the ellipsometry signal and further applied the theory to guide the design of ellipsometry-based biosensor using metal nanoparticles that have a high dielectric constant. Significant signal amplification effects can be achieved by using nanoparticle labels including magnetic nanoparticles and gold nano-particles. Guided by the theory, we have developed a sensitive surface-enhanced imaging ellipsometry (SEIE)-biosensor for detecting chloramphenicol in real milk sample with high sensitivity (with a limit of detection of 6 pg/mL) and broaden detection range. This nanoparticles-enabled SEIE not only greatly improves the sensitivity of conventional imaging ellipsometry-based biosensors but also retains the advantages of conventional methods in terms of automated and convenient operation, providing an effective strategy for detection of trace small molecules in complex samples that holds great promise in scientific research, clinical diagnosis, and food safety. |
DOI | 10.1021/acs.analchem.9b00846 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000469304300051 |
关键词[WOS] | ULTRASENSITIVE DETECTION ; MAGNETIC-RELAXATION ; DISEASE BIOMARKERS ; AMPLIFICATION ; IMMUNOSENSOR |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Analytical |
资助项目 | National Science Foundation of China[81671784] ; Beijing Nova Program[Z181100006218017] |
项目资助者 | National Science Foundation of China ; Beijing Nova Program |
论文分区 | 一类 |
力学所作者排名 | 1 |
RpAuthor | Niu, Yu ; Qi, Cai ; Chen, Yiping |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/79334 |
专题 | 微重力重点实验室 |
推荐引用方式 GB/T 7714 | Wang ZL,Xianyu YL,Liu W,et al. Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing[J]. ANALYTICAL CHEMISTRY,2019,91,10,:6769-6774. |
APA | Wang ZL.,Xianyu YL.,Liu W.,Li YK.,Cai ZX.,...&Chen YP.(2019).Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing.ANALYTICAL CHEMISTRY,91(10),6769-6774. |
MLA | Wang ZL,et al."Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing".ANALYTICAL CHEMISTRY 91.10(2019):6769-6774. |
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