IMECH-IR  > 国家微重力实验室
Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing
Wang ZL; Xianyu YL; Liu W; Li YK; Cai ZX; Fu X; Jin G(靳刚); Niu Y(牛宇); Qi C; Chen YP
Corresponding AuthorNiu, Yu(niuyu@imech.ac.cn) ; Qi, Cai(qicaisucceed1@163.com) ; Chen, Yiping(chenyiping@mail.hzau.edu.cn)
Source PublicationANALYTICAL CHEMISTRY
2019-05-21
Volume91Issue:10Pages:6769-6774
ISSN0003-2700
AbstractThe main issues of imaging ellipsometry-based biosensing for small molecules are the low sensitivity and narrow detection range due to the low molecular weight of small molecules that results in a negligible signal. To meet this challenge, we theoretically investigated the deciding factors of the ellipsometry signal and further applied the theory to guide the design of ellipsometry-based biosensor using metal nanoparticles that have a high dielectric constant. Significant signal amplification effects can be achieved by using nanoparticle labels including magnetic nanoparticles and gold nano-particles. Guided by the theory, we have developed a sensitive surface-enhanced imaging ellipsometry (SEIE)-biosensor for detecting chloramphenicol in real milk sample with high sensitivity (with a limit of detection of 6 pg/mL) and broaden detection range. This nanoparticles-enabled SEIE not only greatly improves the sensitivity of conventional imaging ellipsometry-based biosensors but also retains the advantages of conventional methods in terms of automated and convenient operation, providing an effective strategy for detection of trace small molecules in complex samples that holds great promise in scientific research, clinical diagnosis, and food safety.
DOI10.1021/acs.analchem.9b00846
Indexed BySCI
Language英语
WOS IDWOS:000469304300051
WOS KeywordULTRASENSITIVE DETECTION ; MAGNETIC-RELAXATION ; DISEASE BIOMARKERS ; AMPLIFICATION ; IMMUNOSENSOR
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding ProjectNational Science Foundation of China[81671784] ; Beijing Nova Program[Z181100006218017]
Funding OrganizationNational Science Foundation of China ; Beijing Nova Program
Classification一类
Ranking1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79335
Collection国家微重力实验室
Recommended Citation
GB/T 7714
Wang ZL,Xianyu YL,Liu W,et al. Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing[J]. ANALYTICAL CHEMISTRY,2019,91(10):6769-6774.
APA Wang ZL.,Xianyu YL.,Liu W.,Li YK.,Cai ZX.,...&Chen YP.(2019).Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing.ANALYTICAL CHEMISTRY,91(10),6769-6774.
MLA Wang ZL,et al."Nanoparticles-Enabled Surface-Enhanced Imaging Ellipsometry for Amplified Biosensing".ANALYTICAL CHEMISTRY 91.10(2019):6769-6774.
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