IMECH-IR  > 非线性力学国家重点实验室
Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures
Li L(李龙); Hu JL; Li L; Song F(宋凡)
Corresponding AuthorHu, Jinglei(hujinglei@nju.edu.cn) ; Song, Fan(songf@lnm.imech.ac.cn)
Source PublicationSOFT MATTER
2019-05-07
Volume15Issue:17Pages:3507-3514
ISSN1744-683X
AbstractCell adhesion is crucial for immune response, tissue formation, and cell locomotion. The adhesion process is mediated by the specific binding of membrane-anchored receptor and ligand proteins. These adhesion proteins are in contact with the membranes and may generate curvature, which has been shown for a number of membrane proteins to play an important role in membrane remodeling. An important question remains of whether the local membrane curvatures induced by the adhesion proteins affect their binding. We've performed Monte Carlo simulations of a mesoscopic model for membrane adhesion via the specific binding of curvature-inducing receptors and ligands. We find that the curvatures induced by the adhesion proteins do affect their binding equilibrium constant. We presented a theory that takes into account the membrane deformations and protein-protein interactions due to the induced curvatures, and agrees quantitatively with our simulation results. Our study suggests that the ability to induce membrane curvatures represents a molecular property of the adhesion proteins and should be carefully considered in experimental characterization of the binding affinity.
DOI10.1039/c8sm02504e
Indexed BySCI ; EI
Language英语
WOS IDWOS:000471298900021
WOS KeywordATOMIC-FORCE MICROSCOPY ; VIRIAL-COEFFICIENTS ; KINETICS ; ADHESION ; TCR ; MECHANISMS ; INCLUSIONS ; DIFFUSION ; PROTEINS ; SELF
WOS Research AreaChemistry ; Materials Science ; Physics ; Polymer Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
Funding ProjectNational Key Research and Development Program of China[2016YFA0501601] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[11472285] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
Classification二类/Q1
Ranking1
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79377
Collection非线性力学国家重点实验室
Recommended Citation
GB/T 7714
Li L,Hu JL,Li L,et al. Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures[J]. SOFT MATTER,2019,15(17):3507-3514.
APA 李龙,Hu JL,Li L,&宋凡.(2019).Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures.SOFT MATTER,15(17),3507-3514.
MLA 李龙,et al."Binding constant of membrane-anchored receptors and ligands that induce membrane curvatures".SOFT MATTER 15.17(2019):3507-3514.
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