IMECH-IR  > 国家微重力实验室
Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight
Moser, D.1; Sun, S. J.2,3,4; Li, N.2,3,4; Biere, K.1; Hoerl, M.1; Matzel, S.1; Feuerecker, M.1; Buchheim, J. -I.1; Strewe, C.1; Thiel, C. S.5,6; Gao, Y. X.2,3,4; Wang, C. Z.2,3,4; Ullrich, O.5,6; Long, M.2,3,4; Chouker, A.1
Corresponding AuthorLong, M.(mlong@imech.ac.cn) ; Chouker, A.(alexander.chouker@med.uni-muenchen.de)
Source PublicationSCIENTIFIC REPORTS
2019-08-02
Volume9Pages:11
ISSN2045-2322
AbstractGravitational stress in general and microgravity (mu g) in particular are regarded as major stress factors responsible for immune system dysfunction in space. To assess the effects of alternating mu g and hypergravity (hyper-g) on immune cells, the attachment of peripheral blood mononuclear cells (PBMCs) to adhesion molecules under flow conditions and the antigen-induced immune activation in whole blood were investigated in parabolic flight (PF). In contrast to hyper-g (1.8 g) and control conditions (1 g), flow and rolling speed of PBMCs were moderately accelerated during mu g-periods which were accompanied by a clear reduction in rolling rate. Whole blood analyses revealed a "primed" state of monocytes after PF with potentiated antigen-induced pro-inflammatory cytokine responses. At the same time, concentrations of anti-inflammatory cytokines were increased and monocytes displayed a surface molecule pattern that indicated immunosuppression. The results suggest an immunologic counterbalance to avoid disproportionate immune responses. Understanding the interrelation of immune system impairing and enhancing effects under different gravitational conditions may support the design of countermeasures to mitigate immune deficiencies in space.
DOI10.1038/s41598-019-47655-x
Indexed BySCI ; SCI
Language英语
WOS IDWOS:000478575000063
WOS KeywordPOLYMORPHONUCLEAR LEUKOCYTES ; SIMULATED MICROGRAVITY ; INFLAMMATION ; MIGRATION ; FAMILY
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding ProjectGerman Aerospace Center (DLR) on behalf of the Federal Ministry of Economics and Technology[DLR 50WB1622] ; German Aerospace Center (DLR) on behalf of the Federal Ministry of Economics and Technology[50WB1519] ; Chinese Academy of Sciences[XDA0402020219] ; Chinese Academy of Sciences[XDA04020416] ; Chinese Academy of Sciences[XDA04073800] ; Chinese Academy of Sciences[QYZDJSSW-JSC018] ; Chinese Academy of Sciences[XDA15014100] ; National Natural Science Foundation of China[U1738115] ; National Natural Science Foundation of China[31661143044] ; University of Zurich
Funding OrganizationGerman Aerospace Center (DLR) on behalf of the Federal Ministry of Economics and Technology ; Chinese Academy of Sciences ; National Natural Science Foundation of China ; University of Zurich
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79465
Collection国家微重力实验室
Corresponding AuthorLong, M.; Chouker, A.
Affiliation1.Ludwig Maximilians Univ Munchen, Lab Translat Res Stress & Immun, Dept Anaesthesiol, Univ Hosp, Munich, Germany
2.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
5.Univ Zurich, Inst Anat, Fac Med, Zurich, Switzerland
6.Otto von Guericke Univ, Dept Machine Design Engn Design & Prod Dev IMK, Magdeburg, Germany
Recommended Citation
GB/T 7714
Moser, D.,Sun, S. J.,Li, N.,et al. Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight[J]. SCIENTIFIC REPORTS,2019,9:11.
APA Moser, D..,Sun, S. J..,Li, N..,Biere, K..,Hoerl, M..,...&Chouker, A..(2019).Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight.SCIENTIFIC REPORTS,9,11.
MLA Moser, D.,et al."Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight".SCIENTIFIC REPORTS 9(2019):11.
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