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Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight
Moser D; Sun SJ(孙树津); Li N(李宁); Biere K; Hoerl M; Matzel S; Feuerecker M; Buchheim JI; Strewe C; Thiel CS; Gao YX(高宇欣); Wang CZ(王成之); Ullrich O; Long M(龙勉); Chouker A
Source PublicationSCIENTIFIC REPORTS
2019-08-02
Volume9Pages:11
ISSN2045-2322
Abstract

Gravitational stress in general and microgravity (mu g) in particular are regarded as major stress factors responsible for immune system dysfunction in space. To assess the effects of alternating mu g and hypergravity (hyper-g) on immune cells, the attachment of peripheral blood mononuclear cells (PBMCs) to adhesion molecules under flow conditions and the antigen-induced immune activation in whole blood were investigated in parabolic flight (PF). In contrast to hyper-g (1.8 g) and control conditions (1 g), flow and rolling speed of PBMCs were moderately accelerated during mu g-periods which were accompanied by a clear reduction in rolling rate. Whole blood analyses revealed a "primed" state of monocytes after PF with potentiated antigen-induced pro-inflammatory cytokine responses. At the same time, concentrations of anti-inflammatory cytokines were increased and monocytes displayed a surface molecule pattern that indicated immunosuppression. The results suggest an immunologic counterbalance to avoid disproportionate immune responses. Understanding the interrelation of immune system impairing and enhancing effects under different gravitational conditions may support the design of countermeasures to mitigate immune deficiencies in space.

DOI10.1038/s41598-019-47655-x
Indexed BySCI
Language英语
WOS IDWOS:000478575000063
Classification二类/Q1
Ranking1
ContributorLong, M.(mlong@imech.ac.cn)
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79502
Collection国家微重力实验室
Recommended Citation
GB/T 7714
Moser D,Sun SJ,Li N,et al. Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight[J]. SCIENTIFIC REPORTS,2019,9:11.
APA Moser D.,Sun SJ.,Li N.,Biere K.,Hoerl M.,...&Chouker A.(2019).Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight.SCIENTIFIC REPORTS,9,11.
MLA Moser D,et al."Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight".SCIENTIFIC REPORTS 9(2019):11.
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