IMECH-IR  > 非线性力学国家重点实验室
Adsorption of Phospholipids at the Air-Water Surface
Bai X(白轩)1,2,3; Xu L4; Tang JY4; Zuo YY4,5; Hu GQ(胡国庆)1
Corresponding AuthorZuo, Yi Y.(yzuo@hawaii.edu) ; Hu, Guoqing(ghu@zju.edu.cn)
Source PublicationBIOPHYSICAL JOURNAL
2019-10-01
Volume117Issue:7Pages:1224-1233
ISSN0006-3495
AbstractPhospholipids are ubiquitous components of biomembranes and common biomaterials used in many bioengineering applications. Understanding adsorption of phospholipids at the air-water surface plays an important role in the study of pulmonary surfactants and cell membranes. To date, however, the biophysical mechanisms of phospholipid adsorption are still unknown. It is challenging to reveal the molecular structure of adsorbed phospholipid films. Using combined experiments with constrained drop surfactometry and molecular dynamics simulations, here, we studied the biophysical mechanisms of dipalmitoylphosphatidylcholine (DPPC) adsorption at the air-water surface. It was found that the DPPC film adsorbed from vesicles showed distinct equilibrium surface tensions from the DPPC monolayer spread via organic solvents. Our simulations revealed that only the outer leaflet of the DPPC vesicle is capable of unzipping and spreading at the air-water surface, whereas the inner leaflet remains intact and forms an inverted micelle to the interfacial monolayer. This inverted micelle increases the local curvature of the monolayer, thus leading to a loosely packed monolayer at the air-water surface and hence a higher equilibrium surface tension. These findings provide novel insights, to our knowledge, into the mechanism of the phospholipid and pulmonary surfactant adsorption and may help understand the structure-function correlation in biomembranes.
DOI10.1016/j.bpj.2019.08.022
Indexed BySCI ; EI
Language英语
WOS IDWOS:000488457600006
WOS KeywordCOARSE-GRAINED MODEL ; PULMONARY SURFACTANT ; LUNG SURFACTANT ; LIPID-BILAYERS ; COMPETITIVE ADSORPTION ; HYDROPHOBIC SURFACES ; TENSION MEASUREMENTS ; MOLECULAR-MECHANISM ; DYNAMIC ADSORPTION ; SP-B
WOS Research AreaBiophysics
WOS SubjectBiophysics
Funding ProjectNatural Science Foundation of China[11832017] ; Natural Science Foundation of China[11572334] ; Natural Science Foundation of China[91543125] ; Chinese Academy of Sciences Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; Chinese Academy of Sciences Strategic Priority Research Program[XDB22040403] ; National Science Foundation[CBET-1604119] ; Hawai'i Community Foundation[18ADVC-90802]
Funding OrganizationNatural Science Foundation of China ; Chinese Academy of Sciences Key Research Program of Frontier Sciences ; Chinese Academy of Sciences Strategic Priority Research Program ; National Science Foundation ; Hawai'i Community Foundation
Classification一类/力学重要期刊
Ranking1
ContributorZuo, Yi Y. ; Hu, Guoqing
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/80661
Collection非线性力学国家重点实验室
Affiliation1.Zhejiang Univ, Dept Engn Mech, Hangzhou, Zhejiang, Peoples R China;
2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China;
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China;
4.Univ Hawaii Manoa, Dept Mech Engn, John A Burns Sch Med, Honolulu, HI 96822 USA;
5.Univ Hawaii Manoa, Dept Pediat, John A Burns Sch Med, Honolulu, HI 96822 USA
Recommended Citation
GB/T 7714
Bai X,Xu L,Tang JY,et al. Adsorption of Phospholipids at the Air-Water Surface[J]. BIOPHYSICAL JOURNAL,2019,117(7):1224-1233.
APA 白轩,Xu L,Tang JY,Zuo YY,&胡国庆.(2019).Adsorption of Phospholipids at the Air-Water Surface.BIOPHYSICAL JOURNAL,117(7),1224-1233.
MLA 白轩,et al."Adsorption of Phospholipids at the Air-Water Surface".BIOPHYSICAL JOURNAL 117.7(2019):1224-1233.
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