IMECH-IR  > 国家微重力实验室
Cell Growth and Differentiation Under Microgravity
Sun SJ(孙树津); Wang CZ(王成之); Li N(李宁); Lv DY(吕东媛); Chen Q(陈琴); Long M(龙勉)
Other AbstractThe mechano-biological coupling mechanism of cell response to altered gravity is crucial to understand physiological changes of astronauts in space microgravity environment and to develop relevant countermeasures. To address this issue, a novel space cell culture hardware mainly consisting of precisely controlled flow chamber and gas exchange unit is developed as an experimental payload in SJ-10 recoverable microgravity experimental satellite. Endothelial cells (ECs) and mesenchymal stem cells (MSCs) are cultured in the hardware during the SJ-10 mission, and recovered samples are analysed elaboratively. The results indicate that microgravity can suppress cellular metabolism. MSCs cultured with hepatic inducing medium are preferential in hepatic differentiation at long-term duration under microgravity. Both ECs and MSCs are regulated by microgravity and respond differentially in initiating cytoskeletal remodeling, or dysregulating signaling pathways relevant to cell adhesion, or directing hepatic differentiation.
Source PublicationLife Science in Space: Experiments on Board the SJ-10 Recoverable Satellite
Publication PlaceBeijing;Singapore
Document Type图书章节
Recommended Citation
GB/T 7714
Sun SJ,Wang CZ,Li N,et al. Cell Growth and Differentiation Under Microgravity[Ch]. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite,Springer,2019.
Files in This Item:
File Name/Size DocType Version Access License
Chap2019007.pdf(1205KB)图书章节 开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[孙树津]'s Articles
[王成之]'s Articles
[李宁]'s Articles
Baidu academic
Similar articles in Baidu academic
[孙树津]'s Articles
[王成之]'s Articles
[李宁]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[孙树津]'s Articles
[王成之]'s Articles
[李宁]'s Articles
Terms of Use
No data!
Social Bookmark/Share

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.