| Magnetic Actuation of Flexible Microelectrode Arrays for Neural Activity Recordings | |
| Gao L1,2; Wang JF1,4; Guan SL1,2; Du MD1,2,6; Wu K(吴坤)5; Xu K1,2; Zou L1,2; Tian HH1; Fang Y1,2,3 | |
| 通讯作者 | Fang, Ying(fangy@nanoctr.cn) |
| 发表期刊 | NANO LETTERS
 |
| 2019-11-01 | |
| 卷号 | 19期号:11页码:8032-8039 |
| ISSN | 1530-6984 |
| 摘要 | Implantable microelectrodes that can be remotely actuated via external fields are promising tools to interface with biological systems at a high degree of precision. Here, we report the development of flexible magnetic microelectrodes (FM mu Es) that can be remotely actuated by magnetic fields. The FM mu Es consist of flexible microelectrodes integrated with dielectrically encapsulated FeNi (iron-nickel) alloy microactuators. Both magnetic torque- and force-driven actuation of the EM mu Es have been demonstrated. Nanoplatinum-coated FM mu Es have been applied for in vivo recordings of neural activities from peripheral nerves and cerebral cortex of mice. Moreover, owing to their ultrasmall sizes and mechanical compliance with neural tissues, chronically implanted FM mu Es elicited greatly reduced neuronal cell loss in mouse brain compared to conventional stiff probes. The FM mu Es open up a variety of new opportunities for electrically interfacing with biological systems in a controlled and minimally invasive manner. |
| 关键词 | flexible microelectrode magnetic actuation nanoscale roughness neural recording inflammatory response |
| DOI | 10.1021/acs.nanolett.9b03232 |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000497259300055 |
| 关键词[WOS] | TISSUE-RESPONSE ; BRAIN-TISSUE ; ELECTRODES ; SYSTEM ; MICROROBOTS ; POTENTIALS ; IMPLANTS ; CORTEX ; CELLS ; FILMS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030100] ; National Natural Science Foundation of China[21790393] ; National Natural Science Foundation of China[21673057] ; Frontier Research Program of the Chinese Academy of Sciences[QYZDB-SSW-SLH044] ; Fabrication Lab at NCNST |
| 项目资助者 | Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Frontier Research Program of the Chinese Academy of Sciences ; Fabrication Lab at NCNST |
| 论文分区 | 一类 |
| 力学所作者排名 | 5 |
| RpAuthor | Fang, Ying |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/81217 |
| 专题 | 高温气体动力学国家重点实验室 |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China; 4.Chinese Acad Sci, State Key Labs Transducer Technol, Beijing 100190, Peoples R China; 5.Chinese Acad Sci, Inst Mech, State Key Lab High Temp Gas Dynam, Beijing 100190, Peoples R China; 6.Aalto Univ, Dept Elect & Nanoengn, FI-00076 Espoo, Finland |
| 推荐引用方式 GB/T 7714 | Gao L,Wang JF,Guan SL,et al. Magnetic Actuation of Flexible Microelectrode Arrays for Neural Activity Recordings[J]. NANO LETTERS,2019,19,11,:8032-8039. |
| APA | Gao L.,Wang JF.,Guan SL.,Du MD.,吴坤.,...&Fang Y.(2019).Magnetic Actuation of Flexible Microelectrode Arrays for Neural Activity Recordings.NANO LETTERS,19(11),8032-8039. |
| MLA | Gao L,et al."Magnetic Actuation of Flexible Microelectrode Arrays for Neural Activity Recordings".NANO LETTERS 19.11(2019):8032-8039. |
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| Jp2019493.pdf（7003KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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