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Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway
Wu XS1,2; Hu JR(胡锦荣)3,4,5; Li GQ1; Li Y1,6; Li Y1; Zhang J1; Wang F1,7; Li A1,8; Hu L1; Fan ZP1; Lu SQ3,4,5; Ding G1,9; Zhang CM1; Wang JS10; Long M(龙勉)3,4,5; Wang SL1,10
Source PublicationEMBO JOURNAL
2020-02-03
Volume39Issue:3Pages:19
ISSN0261-4189
Abstract

Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but the mechanism that initiates each cycle remains largely unknown. In a miniature pig model of tooth development that resembles tooth development in humans, the permanent tooth did not begin transitioning from the resting to the initiation stage until the deciduous tooth began to erupt. This eruption released the accumulated mechanical stress inside the mandible. Mechanical stress prevented permanent tooth development by regulating expression and activity of the integrin beta 1-ERK1-RUNX2 axis in the surrounding mesenchyme. We observed similar molecular expression patterns in human tooth germs. Importantly, the release of biomechanical stress induced downregulation of RUNX2-wingless/integrated (Wnt) signaling in the mesenchyme between the deciduous and permanent tooth and upregulation of Wnt signaling in the epithelium of the permanent tooth, triggering initiation of its development. Consequently, our findings identified biomechanical stress-associated Wnt modulation as a critical initiator of organ renewal, possibly shedding light on the mechanisms of integumentary organ regeneration.

Keywordbiomechanics organ replacement stress Wnt signaling
DOI10.15252/embj.2019102374
Indexed BySCI
Language英语
WOS IDWOS:000502188700001
WOS KeywordDENTAL LAMINA ; DIFFERENTIAL GROWTH ; ARTICULAR-CARTILAGE ; MECHANICAL TENSION ; WNT ; REGENERATION ; DENTITION ; TEETH ; IDENTIFICATION ; CONTRIBUTES
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
Funding ProjectChinese Academy of Medical Sciences Research Unit[2019RU020] ; Capital Medical University, Beijing Municipality Government[PXM2018_014226_000021] ; Capital Medical University, Beijing Municipality Government[PXM2017_014226_000023] ; Capital Medical University, Beijing Municipality Government[PXM2018_193312_000006_0028S643_FCG PXM2016_014226_000034] ; Capital Medical University, Beijing Municipality Government[PXM2016_014226_000006] ; Capital Medical University, Beijing Municipality Government[PXM2015_014226_000116] ; Capital Medical University, Beijing Municipality Government[PXM2015_ 014226_000055] ; Capital Medical University, Beijing Municipality Government[PXM2015_014226_000052] ; National Natural Science Foundation of China[91649124] ; National Natural Science Foundation of China[81400478] ; National Natural Science Foundation of China[31661143044] ; National Natural Science Foundation of China[PXM2014_014226_000048] ; National Natural Science Foundation of China[PXM2014_014226_000013] ; National Natural Science Foundation of China[PXM2014_014226_000053] ; National Natural Science Foundation of China[Z121100005212004] ; National Natural Science Foundation of China[PXM2013_014226_000055] ; National Natural Science Foundation of China[PXM2013_014226_000021] ; National Natural Science Foundation of China[TJSHG201310025005]
Funding OrganizationChinese Academy of Medical Sciences Research Unit ; Capital Medical University, Beijing Municipality Government ; National Natural Science Foundation of China
Classification一类
Ranking2
ContributorWang, Songlin
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/81233
Collection国家微重力实验室
Affiliation1.Capital Med Univ, Sch Stomatol, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Beijing, Peoples R China;
2.Cent S Univ, Xiangya Hosp, Dept Oral & Maxillofacial Surg, Changsha, Hunan, Peoples R China;
3.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing, Peoples R China;
4.Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing, Peoples R China;
5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China;
6.Fortune Link Triones Scitech Co Ltd, Beijing, Peoples R China;
7.Dalian Med Univ, Sch Stomatol, Dept Oral Basic Sci, Dalian, Peoples R China;
8.Xi An Jiao Tong Univ, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Coll Stomatol, Xian, Shaanxi, Peoples R China;
9.Weifang Med Univ, Dept Stomatol, Yidu Cent Hosp, Weifang, Peoples R China;
10.Capital Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wu XS,Hu JR,Li GQ,et al. Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway[J]. EMBO JOURNAL,2020,39(3):19.
APA Wu XS.,Hu JR.,Li GQ.,Li Y.,Li Y.,...&Wang SL.(2020).Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway.EMBO JOURNAL,39(3),19.
MLA Wu XS,et al."Biomechanical stress regulates mammalian tooth replacement via the integrin beta 1-RUNX2-Wnt pathway".EMBO JOURNAL 39.3(2020):19.
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