IMECH-IR  > 非线性力学国家重点实验室
Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes
Li L(李龙)1,2; Hu JL3,4; Rozycki B5; Song F(宋凡)1,2,6
Corresponding AuthorHu, Jinglei(hujinglei@nju.edu.cn) ; Rozycki, Bartosz(rozycki@ifpan.edu.pl) ; Song, Fan(songf@lnm.imech.ac.cn)
Source PublicationNANO LETTERS
2020
Volume20Issue:1Pages:722-728
ISSN1530-6984
AbstractNanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor ligand binding and membrane shape fluctuations can lead to receptor aggregation within the adhering membranes even if large-scale clusters are thermodynamically unstable in nonadhering membranes.
Keywordcell membrane adhesion receptor proteins nanoscale lipid clusters thermal fluctuations Monte Carlo simulations
DOI10.1021/acs.nanolett.9b04596
Indexed BySCI ; EI
Language英语
WOS IDWOS:000507151600094
WOS KeywordLIPID RAFTS ; ANCHORED RECEPTORS ; MOLECULES ; ADHESION ; MYSTERY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding ProjectNational Key Research and Development Program of China[2016YFA0501601] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland[2016/21/B/NZ1/00006]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; National Science Centre, Poland
Classification一类
Ranking1
ContributorHu, Jinglei ; Rozycki, Bartosz ; Song, Fan
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/81295
Collection非线性力学国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China;
2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China;
3.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210023, Peoples R China;
4.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China;
5.Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, PL-02668 Warsaw, Poland;
6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li L,Hu JL,Rozycki B,et al. Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes[J]. NANO LETTERS,2020,20(1):722-728.
APA 李龙,Hu JL,Rozycki B,&宋凡.(2020).Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.NANO LETTERS,20(1),722-728.
MLA 李龙,et al."Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes".NANO LETTERS 20.1(2020):722-728.
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