IMECH-IR  > 非线性力学国家重点实验室
Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks
Li YK1,2; Liu C1,2; Bai X(白轩)2,4; Tian F1,2; Hu GQ(胡国庆)3; Sun JS1,2
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020-01-24
Pages6
ISSN1433-7851
Abstract

Chiral analysis of bioactive molecules is of increasing significance in chemical and life sciences. However, the quantitative detection of a racemic mixture of enantiomers is a challenging task, which relies on complicated and time-consuming multiple steps of chiral derivatization, chiral separation, and spectroscopic measurement. Herein, we show that, without the use of chiral molecules or pretreatment steps, the co-assembly of amino acids with achiral TPPS4 monomers controlled by enantiomorphic microvortices allows quantitative detection of racemic or enantiomeric amino acids, through analysis of the sign and magnitude of supramolecular chirality in different outlets of a microfluidic platform. A model demonstrates that chiral microvortices can induce an initial chiral bias by bending the sheet structure, resulting in supramolecular self-assembly of TPPS4 and amino acids of compatible chirality by the self-sorting. This sensing system may find versatile applications in chiral sensing.

Keywordchirality detection enantiomorphic microvortices racemic amino acids supramolecules
DOI10.1002/anie.201913882
Indexed BySCI ; EI
Language英语
WOS IDWOS:000509299100001
WOS KeywordHYDRODYNAMIC-FORCES ; CHIRALITY ; SELECTION ; VORTICES ; ORIGINS ; SYSTEMS ; ALANINE
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding ProjectNational Natural Science Foundation of China[21622503] ; National Natural Science Foundation of China[21904028] ; Chinese Academy of Sciences[YJKYYQ20180055] ; Chinese Academy of Sciences[ZDBS-LY-SLH025] ; Youth Innovation Promotion Association CAS[2016035]
Funding OrganizationNational Natural Science Foundation of China ; Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS
Classification一类
Ranking3
ContributorSun, Jiashu
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/81297
Collection非线性力学国家重点实验室
Affiliation1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China;
2.Univ Chinese Acad Sci, Sch Future Technol, Beijing 100149, Peoples R China;
3.Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Peoples R China;
4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li YK,Liu C,Bai X,et al. Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6.
APA Li YK,Liu C,Bai X,Tian F,Hu GQ,&Sun JS.(2020).Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6.
MLA Li YK,et al."Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6.
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