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Nanoparticle translocation across the lung surfactant film regulated by grafting polymers
Bai X(白轩)1,2,3; Li MJ(李木均)2,3; Hu GQ(胡国庆)1
Corresponding AuthorHu, Guoqing(ghu@zju.edu.cn)
Source PublicationNANOSCALE
2020-02-14
Volume12Issue:6Pages:3931-3940
ISSN2040-3364
AbstractNanoparticle-based pulmonary drug delivery has gained significant attention due to its ease of administration, increased bioavailability, and reduced side effects caused by a high systemic dosage. After being delivered into the deep lung, the inhaled nanoparticles first interact with the lung surfactant lining layer composed of phospholipids and surfactant proteins and then potentially cause the dysfunction of the lung surfactant. Conditioning the surface properties of nanoparticles with grafting polymers to avoid these side effects is of crucial importance to the efficiency and safety of pulmonary drug delivery. Herein, we perform coarse-grained molecular simulations to decipher the involved mechanism responsible for the translocation of the polymer-grafted Au nanoparticles across the lung surfactant film. The simulations illustrate that conditioning of the grafting polymers, including their length, terminal charge, and grafting density, can result in different translocation processes. Based on the energy analysis, we find that these discrepancies in translocation stem from the affinity of the nanoparticles with the lipid tails and heads and their contact with the proteins, which can be tuned by the surface polarity and surface charge of the nanoparticles. We further demonstrate that the interaction between the nanoparticles and the lung surfactant is related to the depletion of the lipids and proteins during translocation, which affects the surface tension of the surfactant film. The change in the surface tension in turn affects the nanoparticle translocation and the collapse of the surfactant film. These results can help understand the adverse effects of the nanoparticles on the lung surfactant film and provide guidance to the design of inhaled nanomedicines for improved permeability and targeting.
DOI10.1039/c9nr09251j
Indexed BySCI ; EI
Language英语
WOS IDWOS:000515391000037
WOS KeywordPULMONARY SURFACTANT ; BIOPHYSICAL INHIBITION ; INTERFACIAL PROPERTIES ; SILICA NANOPARTICLES ; LIPID MONOLAYER ; DRUG-DELIVERY ; PROTEIN-B ; MEMBRANES ; DYNAMICS ; ADSORPTION
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding ProjectNSFC[11832017] ; NSFC[11572334] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program[XDB22040403]
Funding OrganizationNSFC ; CAS Key Research Program of Frontier Sciences ; CAS Strategic Priority Research Program
Classification一类
Ranking1
ContributorHu, Guoqing
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/81554
Collection非线性力学国家重点实验室
Affiliation1.Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Zhejiang, Peoples R China;
2.Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Inst Mech, Beijing 100190, Peoples R China;
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Bai X,Li MJ,Hu GQ. Nanoparticle translocation across the lung surfactant film regulated by grafting polymers[J]. NANOSCALE,2020,12,6,:3931-3940.
APA 白轩,李木均,&胡国庆.(2020).Nanoparticle translocation across the lung surfactant film regulated by grafting polymers.NANOSCALE,12(6),3931-3940.
MLA 白轩,et al."Nanoparticle translocation across the lung surfactant film regulated by grafting polymers".NANOSCALE 12.6(2020):3931-3940.
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