Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein

doi:10.1016/j.apsb.2019.10.002

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	Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein
	Dong WJ 1,2,3; Ye J 1,2,3; Zhou JZ 1,2,3; Wang WJ 1,2,3; Wang HL 1,2,3; Zheng X(郑旭)4; Yang YF 1,2,3; Xia XJ 1,2,3; Liu YL 1,2,3
通讯作者	Liu, Yuling(ylliu@imm.ac.cn)
发表期刊	ACTA PHARMACEUTICA SINICA B
	2020-08-01
卷号	10 期号:8 页码:1576-1585
ISSN	2211-3835
摘要	Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within the respiratory tract mucus. However, the interaction between nanoparticles and mucus, and how these interactions impact distribution has not been extensively investigated. In this study, polymeric nanoparticles loaded with a baicalein-phospholipid complex were modified with two kinds of polymers, mucoadhesive and mucus-penetrative polymer. Systematic investigations on the physicochemical property, mucus penetration, transepithelial transport, and tissue distribution were performed to evaluate the interaction of nanoparticles with the respiratory tract. Both nanoparticles had a similar particle size and good biocompatibility, exhibited a sustained-release profile, but showed a considerable difference in zeta potential. Interestingly, mucus-penetrative nanoparticles exhibited a higher diffusion rate in mucus, deeper penetration across the mucus layer, enhanced in vitro cellular uptake, increased drug distribution in airways, and superior local distribution and bioavailability as compared to mucoadhesive nanoparticles. These results indicate the potential of mucus-penetrative nanoparticles in design of a rational delivery system to improve the efficiency of inhaled therapy by promoting mucus penetration and increasing local distribution and bioavailability. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
关键词	Nanoparticles Inhaled delivery Mucus-penetrative Mucoadhesive Baicalein
DOI	10.1016/j.apsb.2019.10.002
收录类别	SCI
语种	英语
WOS记录号	WOS:000567649600016
关键词[WOS]	BIODEGRADABLE NANOPARTICLES ; PULMONARY DELIVERY ; PACLITAXEL ; BIOAVAILABILITY ; ABSORPTION ; INHALATION ; THERAPY
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
资助项目	National Science and Technology Major Project of China[2018ZX09721003] ; National Science and Technology Major Project of China[2018ZX09711001]
项目资助者	National Science and Technology Major Project of China
论文分区	一类
力学所作者排名	5+
RpAuthor	Liu, Yuling
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/85214
专题	非线性力学国家重点实验室
作者单位	1.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; 2.Peking Union Med Coll, Beijing 100050, Peoples R China; 3.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel For, Beijing 100050, Peoples R China; 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Dong WJ,Ye J,Zhou JZ,et al. Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein[J]. ACTA PHARMACEUTICA SINICA B,2020,10,8,:1576-1585.
APA	Dong WJ.,Ye J.,Zhou JZ.,Wang WJ.,Wang HL.,...&Liu YL.(2020).Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein.ACTA PHARMACEUTICA SINICA B,10(8),1576-1585.
MLA	Dong WJ,et al."Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein".ACTA PHARMACEUTICA SINICA B 10.8(2020):1576-1585.

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