IMECH-IR  > 非线性力学国家重点实验室
Tuning cell adhesion on supported lipid bilayers via nanoscale geometry
Li L(李龙)1,2; Gao J3,4; Shao YF(邵颖峰)1,2; Song F(宋凡)1,2,5; Hu JL3,4
Corresponding AuthorShao, Yingfeng(shaoyf@lnm.imech.ac.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn)
Source PublicationSOFT MATTER
2021-10-20
Pages7
ISSN1744-683X
AbstractThe cell-supported lipid bilayer (SLB) adhesion system has been widely used as the model system to study the receptor-ligand interactions that occur at the membrane interface. The ligand-functionalized SLBs are deposited either directly on solids or on polymer cushions. An important question that arises is whether the geometry of the SLB affects the binding of cell adhesion receptors to the ligands. By using a mesoscopic mechanical model and Monte Carlo simulations, we have investigated the adhesion of a fluid membrane to a corrugated or egg-carton shaped SLB. We find that the nanoscale geometry of the SLB strongly affects the receptor-ligand binding. This effect results from the fact that the adhering membrane bends according to the SLB geometry in order for the adhesion receptors to bind ligands. The membrane bending couples with spatial distribution of the receptor-ligand complexes and membrane thermal undulations. Our results demonstrate that cell adhesion to SLBs can be controlled by tuning the nanoscale geometry of the SLB, and may have profound implications for future development of tissue engineering and regenerative medicine.
DOI10.1039/d1sm01407b
Indexed BySCI ; EI
Language英语
WOS IDWOS:000715423600001
WOS KeywordMEMBRANE-ANCHORED RECEPTORS ; BINDING ; KINETICS ; LIGANDS ; CONSTANTS ; ANTIGEN ; RAFTS ; SELF
WOS Research AreaChemistry ; Materials Science ; Physics ; Polymer Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
Funding ProjectNational Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[21504038] ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
Funding OrganizationNational Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences
Classification二类
Ranking1
ContributorShao, Yingfeng ; Hu, Jinglei
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/87896
Collection非线性力学国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China;
2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China;
3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China;
4.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China;
5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li L,Gao J,Shao YF,et al. Tuning cell adhesion on supported lipid bilayers via nanoscale geometry[J]. SOFT MATTER,2021:7.
APA 李龙,Gao J,邵颖峰,宋凡,&Hu JL.(2021).Tuning cell adhesion on supported lipid bilayers via nanoscale geometry.SOFT MATTER,7.
MLA 李龙,et al."Tuning cell adhesion on supported lipid bilayers via nanoscale geometry".SOFT MATTER (2021):7.
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