Tuning cell adhesion on supported lipid bilayers via nanoscale geometry

doi:10.1039/d1sm01407b

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	Tuning cell adhesion on supported lipid bilayers via nanoscale geometry
	Li L(李龙)1,2 ; Gao J 3,4; Shao YF(邵颖峰)1,2 ; Song F(宋凡)1,2,5 ; Hu JL3,4
通讯作者	Shao, Yingfeng(shaoyf@lnm.imech.ac.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn)
发表期刊	SOFT MATTER
	2021-10-20
页码	7
ISSN	1744-683X
摘要	The cell-supported lipid bilayer (SLB) adhesion system has been widely used as the model system to study the receptor-ligand interactions that occur at the membrane interface. The ligand-functionalized SLBs are deposited either directly on solids or on polymer cushions. An important question that arises is whether the geometry of the SLB affects the binding of cell adhesion receptors to the ligands. By using a mesoscopic mechanical model and Monte Carlo simulations, we have investigated the adhesion of a fluid membrane to a corrugated or egg-carton shaped SLB. We find that the nanoscale geometry of the SLB strongly affects the receptor-ligand binding. This effect results from the fact that the adhering membrane bends according to the SLB geometry in order for the adhesion receptors to bind ligands. The membrane bending couples with spatial distribution of the receptor-ligand complexes and membrane thermal undulations. Our results demonstrate that cell adhesion to SLBs can be controlled by tuning the nanoscale geometry of the SLB, and may have profound implications for future development of tissue engineering and regenerative medicine.
DOI	10.1039/d1sm01407b
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000715423600001
关键词[WOS]	MEMBRANE-ANCHORED RECEPTORS ; BINDING ; KINETICS ; LIGANDS ; CONSTANTS ; ANTIGEN ; RAFTS ; SELF
WOS研究方向	Chemistry ; Materials Science ; Physics ; Polymer Science
WOS类目	Chemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
资助项目	National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[21504038] ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
项目资助者	National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences
论文分区	二类
力学所作者排名	1
RpAuthor	Shao, Yingfeng ; Hu, Jinglei
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/87896
专题	非线性力学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China; 3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China; 4.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China; 5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li L,Gao J,Shao YF,et al. Tuning cell adhesion on supported lipid bilayers via nanoscale geometry[J]. SOFT MATTER,2021:7.
APA	李龙,Gao J,邵颖峰,宋凡,&Hu JL.(2021).Tuning cell adhesion on supported lipid bilayers via nanoscale geometry.SOFT MATTER,7.
MLA	李龙,et al."Tuning cell adhesion on supported lipid bilayers via nanoscale geometry".SOFT MATTER (2021):7.

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