Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation

doi:10.1016/j.bpj.2021.09.020

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	Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation
	Wang, Tianhao 1; Lv SQ(吕守芹)2,3 ; Hao, Yinjing 1; Su, Zinan 1; Long M(龙勉)2,3 ; Cui, Yuhong 1
通讯作者	Long, Mian(mlong@imech.ac.cn) ; Cui, Yuhong(yhcui@tju.edu.cn)
发表期刊	BIOPHYSICAL JOURNAL
	2021-11-02
卷号	120 期号:21 页码:4859-4873
ISSN	0006-3495
摘要	Hepatic sinusoids present complex anatomical structures such as the endothelial sieve pores and the Disse space, which govern the microscopic blood flow in the sinusoids and are associated with structural variations in liver fibrosis and cirrhosis. However, the contributions of the permeability of endothelial and collagen layers and the roughness of hepatocyte microvilli to the features of this microflow remain largely unknown. Here, an immersed boundary method coupled with a lattice Boltzmann method was adopted in an in vitro hepatic sinusoidal model, and flow field and erythrocyte deformation analyses were conducted by introducing three new source terms including permeability of the endothelial layer, resistance of hepatocyte micro-villi and collagen layers, and deformation of red blood cells (RBCs). Numerical calculations indicated that alterations in endothe-lial permeability could significantly affect the flow velocity and flow rate distributions in hepatic sinusoids. Interestingly, a biphasic regulating pattern of shear stress occurred simultaneously on the surface of hepatocytes and the lower side of endothelium, i.e., the shear stress increased with increased thickness of hepatocyte microvilli and collagen layer when the endothelial permeability was high but decreased with the increase of the thickness at low endothelial permeability. Additionally, this specified microflow manipulates typical RBC deformation inside the sinusoid, yielding one-third of the variation of deformable index with varied endo-thelial permeability. These simulations not only are consistent with experimental measurements using in vitro liver sinusoidal chip but also elaborate the contributions of endothelial and collagen layer permeability and wall roughness. Thus, our results provide a basis for further characterizing this microflow and understanding its effects on cellular migration and deformation in the hepatic sinusoids.
DOI	10.1016/j.bpj.2021.09.020
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000716322100020
关键词[WOS]	ENDOTHELIAL GLYCOCALYX ; LIQUID FLOW ; FIBROSIS
WOS研究方向	Biophysics
WOS类目	Biophysics
资助项目	National Natural Science Foundation of China[11972252] ; Frontier Science Key Project of Chinese Science Academy[QYZDJ-SSW-JSC018] ; Tianjin Natural Science Foundation[17JCYBJC29300]
项目资助者	National Natural Science Foundation of China ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation
论文分区	一类/力学重要期刊
力学所作者排名	1
RpAuthor	Long, Mian ; Cui, Yuhong
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/87955
专题	微重力重点实验室
作者单位	1.Tianjin Univ, Sch Mech Engn, Tianjin, Peoples R China; 2.Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing Key Lab Engn Construct & Mechanobiol, Key Lab Micrograv,Natl Micrograv Lab,Inst Mech, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Wang, Tianhao,Lv SQ,Hao, Yinjing,et al. Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation[J]. BIOPHYSICAL JOURNAL,2021,120,21,:4859-4873.
APA	Wang, Tianhao,吕守芹,Hao, Yinjing,Su, Zinan,龙勉,&Cui, Yuhong.(2021).Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation.BIOPHYSICAL JOURNAL,120(21),4859-4873.
MLA	Wang, Tianhao,et al."Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation".BIOPHYSICAL JOURNAL 120.21(2021):4859-4873.

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