Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant | |
Bai X(白轩)1; Lam, Sin Man2,3; Nie PC(聂鹏程)4,5; Xu, Ming5,6; Liu, Sijin5,6; Shui, Guanghou2,5; Hu, Guoqing1 | |
发表期刊 | ENVIRONMENTAL SCIENCE-NANO |
2022-09-26 | |
页码 | 4150-4161 |
ISSN | 2051-8153 |
摘要 | The large respiratory surface and high permeability make the lung promising in drug delivery of inhaled nanoparticles (NPs) as a portal and susceptible to nanosized airborne pollutions. Inhaled NPs first interact with the lung surfactant (LS) after depositing in the lung, where NPs tend to adsorb the LS molecules to form a biomolecular corona on their surface. Despite the extensive studies of protein coronas from blood plasma or serum, lipid coronas that are constituted by LS molecules are rarely investigated. Herein, we combine high-performance liquid chromatography-mass spectrometry and molecular dynamics simulation to unravel how a lipid corona is formed on hydrophilic NPs from a natural LS. Experiments demonstrate that positive surface charge, long incubation time, and external sonication can promote the formation of a complete lipid corona with compositions different from the bulk LS. Complementary to the experiments, molecular simulations indicate that the surface charge of NPs plays a vital role in the interactions of NPs with both zwitterionic and anionic lipids, which determines the wrap of the LS bilayer on the NP. In addition, the difference in the lipid composition between the corona and the bulk LS is caused by the affinity of NPs with lipids and the intrinsic structure of lipids. These results suggest that it is possible to control the formation and composition of lipid coronas on hydrophilic NPs by tuning the surface coating of NPs and incubation conditions. |
学科领域 | Chemistry, Multidisciplinary ; Environmental Sciences ; Nanoscience & Nanotechnology |
DOI | 10.1039/d2en00653g |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000864813400001 |
项目资助者 | National Natural Science Foundation of China [11832017] ; Chinese Academy of Sciences Strategic Priority Research Program [XDB22040403] ; National Key R&D Program of China [2018YFA0800901, 2018YFA0506900] ; China National Postdoctoral Program for In11ative Talents [BX20200298] |
论文分区 | 一类 |
力学所作者排名 | 3+ |
RpAuthor | Hu, GQ (corresponding author), Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Dept Engn Mech, Hangzhou, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/90161 |
专题 | 非线性力学国家重点实验室 |
作者单位 | 1.Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Dept Engn Mech, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China 3.LipidALL Technol Co Ltd, Changzhou, Jiangsu, Peoples R China 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Bai X,Lam, Sin Man,Nie PC,et al. Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant[J]. ENVIRONMENTAL SCIENCE-NANO,2022:4150-4161. |
APA | Bai X.,Lam, Sin Man.,Nie PC.,Xu, Ming.,Liu, Sijin.,...&Hu, Guoqing.(2022).Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant.ENVIRONMENTAL SCIENCE-NANO,4150-4161. |
MLA | Bai X,et al."Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant".ENVIRONMENTAL SCIENCE-NANO (2022):4150-4161. |
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Jp2022FA153.pdf(1537KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 |
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