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Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer 期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
作者:  Li N(李宁);  Zhang XY(张晓宇);  Zhou J(周瑾);  Li W(李旺);  Shu XY(舒芯钰);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(2553Kb)  |  收藏  |  浏览/下载：313/86  |  提交时间：2022/10/23
Liver tissue stiffness  Shear stress  Hydrostatic pressure  Hepatocytes  Hepatocellular carcinoma  Liver sinusoidal endothelial cells  Hepatic stellate cells  Mechanotransduction pathways  Mechanomedicine  Drug design and delivery  
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
作者:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  收藏  |  浏览/下载：365/101  |  提交时间：2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 卷号: 1864, 期号: 12, 页码: 9
作者:  Li PW(李培文);  Zhou J(周瑾);  Li W(李旺);  Wu H(吴欢);  Hu JR(胡锦荣);  Ding QH(丁奇寒);  Lv SQ(吕守芹);  Pan J;  Zhang CY;  Li N(李宁);  Long M(龙勉)
Adobe PDF(4976Kb)  |  收藏  |  浏览/下载：639/370  |  提交时间：2020/11/30
Liver sinusoidal endothelial cells  Fenestrae  Atomic force microscopy  Imaging recognition  Fully convolutional networks  Substrate stiffness  
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 卷号: 320, 期号: 3, 页码: G272-G282
作者:  Li W(李旺);  Li PW(李培文);  Li N(李宁);  Du Y(杜宇);  Lv SQ(吕守芹);  Elad, David;  Long M(龙勉)
Adobe PDF(2812Kb)  |  收藏  |  浏览/下载：168/82  |  提交时间：2022/10/25
hepatocytes  liver fibrosis  matrix stiffness  shear flow  three-dimensional liver sinusoidal model  
Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography 期刊论文
BIOMATERIALS, 2014, 卷号: 35, 期号: 13, 页码: 3945-3955
作者:  Lv DY(吕东媛);  Luo CH;  Zhang C;  Li Z;  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
Adobe PDF(3274Kb)  |  收藏  |  浏览/下载：1080/380  |  提交时间：2014/06/05
Stiffness  Topography  Stem Cell  Sternness  Morphology  
Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells 期刊论文
BIOMATERIALS, 2013, 卷号: 34, 期号: 31, 页码: 7616-7625
作者:  Li Z(李展);  Gong YW(宫元卫);  Sun SJ(孙树津);  Du Y(杜宇);  Lv DY(吕东媛);  Liu XF(刘晓锋);  Long M(龙勉);  Sun, SJ (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
Adobe PDF(1994Kb)  |  收藏  |  浏览/下载：1897/746  |  提交时间：2013/09/27
Stiffness  Topography  Dimension  Stem Cell  Proliferation  Differentiation  
Spring constant regulate selectin-ligand bond dissociation 会议论文
第五届中美生物医学工程暨海内外生物力学学术研讨会, 中国北京/Beijing, China, 2013-08-01
作者:  Zhang Y(章燕);  Sun GY(孙淦云);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(91Kb)  |  收藏  |  浏览/下载：468/116  |  提交时间：2014/04/02
Dissociation  Regulate  Selectin  Constant  Formation  Further  Increased  Stiffness  Lifetime  Ligand  Binding  Assay  Probe  Force  Kinetics  Mainly  Reverse  Values  Well  Found  
Impact of probe stiffness on receptor-ligand bond dissociation 会议论文
the 3rd Asia Pacific Protein Association Conference in Conjunction with the 3rd Symposium of the Chinese Protein Society, 中国北京/Beijing, China, 2011-05-06
作者:  Zhang Y(章燕);  Sun GY(孙淦云);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(77Kb)  |  收藏  |  浏览/下载：344/80  |  提交时间：2014/04/02
Stiffness  Receptor  Dissociation  Ligand  Probe  Molecule  Probe  Formation  Force  Cario  Barrier  Determine  Metastasis  Mainly  Governed  Irreversible  Bonds  Theorem  Effect  Energy  
Probe stiffness regulates receptor-ligand bond lifetime under force 会议论文
Symposium on Multiscale Modeling and Simulation of Materials/11th International Conference in Asia of the International-Union-of-Materials-Research-Societies, Qingdao, PEOPLES R CHINA, SEP 25-28, 2010
作者:  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉);  Long, MA (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China
Adobe PDF(534Kb)  |  收藏  |  浏览/下载：1392/231  |  提交时间：2012/04/01
Probe Stiffness  Bond Lifetime  Optical Trap  
Probe stiffness regulates receptor-ligand bond lifetime under force 期刊论文
Science China-Physics Mechanics & Astronomy, 2011, 卷号: 54, 期号: 5, 页码: 923-929
作者:  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉);  Long, MA (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100190, Peoples R China
Adobe PDF(534Kb)  |  收藏  |  浏览/下载：1311/248  |  提交时间：2012/04/01
Probe Stiffness  Bond Lifetime  Optical Trap  Selectin Glycoprotein Ligand-1  P-selectin  Cell-adhesion  Binding-kinetics  Leukocytes  Molecule  Psgl-1  Flow