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FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration 期刊论文
BIOMATERIALS, 2024, 卷号: 305, 页码: 17
作者:  Zhang XY(张晓宇);  Li PW(李培文);  Zhou J(周瑾);  Zhang ZL(张子良);  Wu H(吴欢);  Shu XY(舒芯钰);  Li W(李旺);  Wu Y(武亿);  Du Y(杜宇);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
收藏  |  浏览/下载:6/0  |  提交时间:2024/04/02
Liver sinusoidal endothelial cells  Fenestrae  Liver fibrosis  Cytoskeleton remodeling  FAK  MAPK  
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer 期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
作者:  Li N(李宁);  Zhang XY(张晓宇);  Zhou J(周瑾);  Li W(李旺);  Shu XY(舒芯钰);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(2553Kb)  |  收藏  |  浏览/下载:318/88  |  提交时间:2022/10/23
Liver tissue stiffness  Shear stress  Hydrostatic pressure  Hepatocytes  Hepatocellular carcinoma  Liver sinusoidal endothelial cells  Hepatic stellate cells  Mechanotransduction pathways  Mechanomedicine  Drug design and delivery  
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
作者:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  收藏  |  浏览/下载:367/101  |  提交时间:2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 卷号: 1864, 期号: 12, 页码: 9
作者:  Li PW(李培文);  Zhou J(周瑾);  Li W(李旺);  Wu H(吴欢);  Hu JR(胡锦荣);  Ding QH(丁奇寒);  Lv SQ(吕守芹);  Pan J;  Zhang CY;  Li N(李宁);  Long M(龙勉)
Adobe PDF(4976Kb)  |  收藏  |  浏览/下载:644/373  |  提交时间:2020/11/30
Liver sinusoidal endothelial cells  Fenestrae  Atomic force microscopy  Imaging recognition  Fully convolutional networks  Substrate stiffness  
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 卷号: 320, 期号: 3, 页码: G272-G282
作者:  Li W(李旺);  Li PW(李培文);  Li N(李宁);  Du Y(杜宇);  Lv SQ(吕守芹);  Elad, David;  Long M(龙勉)
Adobe PDF(2812Kb)  |  收藏  |  浏览/下载:173/84  |  提交时间:2022/10/25
hepatocytes  liver fibrosis  matrix stiffness  shear flow  three-dimensional liver sinusoidal model  
Influences of Morphology Parameters on the Contact Behavior of a Steel Interface 期刊论文
INTERNATIONAL JOURNAL OF APPLIED MECHANICS, 2020, 卷号: 12, 期号: 1, 页码: 28
作者:  Fan LF;  Zhao L;  Liu XM(刘小明)
Adobe PDF(3218Kb)  |  收藏  |  浏览/下载:969/663  |  提交时间:2020/05/18
Sinusoidal asperities  contact stiffness  elastic-plastic statistical model  18CrMo4 steel interface  morphology parameters  
Mechanical Strength and Structural Basis of beta(2) Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells: A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations 期刊论文
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2018, 卷号: 116, 期号: 2, 页码: 263-279
作者:  Li N(李宁);  Zhang X(张潇);  Li PW;  Yang H;  Tong CF;  Lv SQ(吕守芹);  Zhang Y(章燕);  Ye ZY;  Pan J;  Long M(龙勉)
浏览  |  Adobe PDF(865Kb)  |  收藏  |  浏览/下载:386/188  |  提交时间:2018/10/30
Liver sinusoidal endothelial cells  neutrophils  beta(2) integrin  shear flow  mechanical strength  
Mechanoimmunology of b_2-intergrin-induced adhesion of hepatic cells 会议论文
第九届全国免疫学学术大会, 中国山东济南, 2014-10-18
作者:  Tong CF(佟春芳);  Yang H(杨浩);  Du Y(杜宇);  Li N(李宁);  Lv SQ(吕守芹);  Zhang Y(章燕);  Long M(龙勉)
浏览  |  Adobe PDF(809Kb)  |  收藏  |  浏览/下载:193/45  |  提交时间:2015/09/09
Kupffer  Interact  Sinusoidal  Flowing  Kinetics  Body  Predominantly  Viewpoint  Migrate  Integrin  
The characteristics and estimation of flow through a single rough-walled fracture 期刊论文
JOURNAL OF HYDRODYNAMICS, 2012, 卷号: 24, 期号: 3, 页码: 315-322
作者:  Liu QQ(刘青泉);  Fan HG(樊红光);  Liu, QQ;  Chinese Acad Sci, Inst Mech, Lab Environm Mech, Beijing 100190, Peoples R China.
Adobe PDF(408Kb)  |  收藏  |  浏览/下载:799/242  |  提交时间:2013/01/18
Fracture Seepage  Cubic Law  Effective Hydraulic Aperture  Non-symmetric Sinusoidal Fracture  Rock Joints  Fluid-flow  Equation  Model  Law  
An Approach to Estimate the Flow Through an Irregular Fracture 会议论文
Proceeding of the sixth International Conference on Fluid Mechanics (New Trends in Fluid Mechanics Research), AIP Conf. Proc. Vol. 1376., Guangzhou, China, 2011-06-30~2011-07-03
作者:  Liu QQ(刘青泉);  Fan HG(樊红光)
Adobe PDF(219Kb)  |  收藏  |  浏览/下载:1112/263  |  提交时间:2012/01/13
Fracture Seepage  Cubic Law  Effective Hydraulic Aperture  Non-symmetric Sinusoidal Fracture