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Title:
Double spiral microchannel for label-free tumor cell separation and enrichment
Author: Sun JS; Li MM; Liu C(刘超); Zhang Y; Liu DB; Liu WW; Hu GQ(胡国庆); Jiang XY
Source: LAB ON A CHIP
Issued Date: 2012-06
Volume: 12, Issue:20, Pages:3952-3960
Abstract: This work reports on a passive double spiral microfluidic device allowing rapid and label-free tumor cell separation and enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. A numerical model is developed to simulate the Dean flow inside the curved geometry and to track the particle/cell trajectories, which is validated against the experimental observations and serves as a theoretical foundation for optimizing the operating conditions. Results from separating tumor cells (MCF-7 and Hela) spiked into whole blood indicate that 92.28% of blood cells and 96.77% of tumor cells are collected at the inner and the middle outlet, respectively, with 88.5% tumor recovery rate at a throughput of 3.33 x 10(7) cells min(-1). We expect that this label-free microfluidic platform, driven by purely hydrodynamic forces, would have an impact on fundamental and clinical studies of circulating tumor cells.
Language: 英语
Indexed Type: SCI
Corresponding Author: Sun, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
Correspondent Email: sunjs@nanoctr.cn; guoqing.hu@imech.ac.cn; xingyujiang@nanoctr.cn
DOI: 10.1039/c2lc40679a
Related URLs: 查看原文
WOS Keyword Plus: METASTATIC BREAST-CANCER; PERIPHERAL-BLOOD; DIELECTROPHORETIC SEPARATION; MICROFLUIDIC DEVICES; CARCINOMA-CELLS; PARTICLES; CHIP; SIZE; FLOW; TECHNOLOGY
WOS ID: WOS:000308894600016
ISSN: 1473-0197
Rank: [Sun, Jiashu; Li, Mengmeng; Zhang, Yi; Liu, Dingbin; Liu, Wenwen; Jiang, Xingyu] Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Liu, Chao; Hu, Guoqing] LMN, Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China; [Li, Mengmeng] Qingdao Univ, Coll Phys Sci, Qingdao 266071, Peoples R China
Subject: 流体力学::微机电系统中的流体力学问题
Department: LNM微纳米流体力学
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/47111
Appears in Collections:非线性力学国家重点实验室_期刊论文

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Recommended Citation:
Sun JS,Li MM,Liu C,et al. Double spiral microchannel for label-free tumor cell separation and enrichment[J]. LAB ON A CHIP,2012-06-01,12(20):3952-3960.
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