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Double spiral microchannel for label-free tumor cell separation and enrichment
Sun JS; Li MM; Liu C(刘超); Zhang Y; Liu DB; Liu WW; Hu GQ(胡国庆); Jiang XY; Sun, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
2012-06
发表期刊LAB ON A CHIP
卷号12期号:20页码:3952-3960
ISSN1473-0197
摘要This work reports on a passive double spiral microfluidic device allowing rapid and label-free tumor cell separation and enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. A numerical model is developed to simulate the Dean flow inside the curved geometry and to track the particle/cell trajectories, which is validated against the experimental observations and serves as a theoretical foundation for optimizing the operating conditions. Results from separating tumor cells (MCF-7 and Hela) spiked into whole blood indicate that 92.28% of blood cells and 96.77% of tumor cells are collected at the inner and the middle outlet, respectively, with 88.5% tumor recovery rate at a throughput of 3.33 x 10(7) cells min(-1). We expect that this label-free microfluidic platform, driven by purely hydrodynamic forces, would have an impact on fundamental and clinical studies of circulating tumor cells.
学科领域微机电系统中的流体力学问题
DOI10.1039/c2lc40679a
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收录类别SCI
语种英语
WOS记录号WOS:000308894600016
关键词[WOS]METASTATIC BREAST-CANCER; PERIPHERAL-BLOOD; DIELECTROPHORETIC SEPARATION; MICROFLUIDIC DEVICES; CARCINOMA-CELLS; PARTICLES; CHIP; SIZE; FLOW; TECHNOLOGY
项目资助者MOST [2011CB933201, 2009CB930001, 2011CB707604]; NSFC [51105086, 21025520, 90813032, 50890182]; CAS [KJCX2-YW-M15]
课题组名称LNM微纳米流体力学
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文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/47111
专题非线性力学国家重点实验室
通讯作者Sun, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
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GB/T 7714
Sun JS,Li MM,Liu C,et al. Double spiral microchannel for label-free tumor cell separation and enrichment[J]. LAB ON A CHIP,2012,12(20):3952-3960.
APA Sun JS.,Li MM.,Liu C.,Zhang Y.,Liu DB.,...&Sun, JS .(2012).Double spiral microchannel for label-free tumor cell separation and enrichment.LAB ON A CHIP,12(20),3952-3960.
MLA Sun JS,et al."Double spiral microchannel for label-free tumor cell separation and enrichment".LAB ON A CHIP 12.20(2012):3952-3960.
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