Knowledge Management System of Institue of Mechanics, CAS
Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study | |
Cui XY; Ren QS(任庆帅); Li ZH; Peng K; Li GY; Gu ZY; Qiao AK | |
发表期刊 | CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES |
2018-09-01 | |
卷号 | 116期号:3页码:455-469 |
ISSN | 1526-1492 |
摘要 | Clinical application of bare metal stents is constrained by the occurrence of instent restenosis, mainly due to the complex biomechanical environment in the body. Numerical simulation method was used to evaluate the effect of plaque composition on stent performance in a carotid artery. CT angiography (CTA) data were used as a reference, and zero-load state of the carotid artery was used to establish a 3D stenotic artery model. Different plaque compositions, calcified and hypo-cellular were defined in Model 1 and Model 2, respectively. Interactions between the stents and arterial tissues within the stent crimping-expansion process were analyzed to explore the effects of plaque composition on the mechanical parameters of carotid stents. Goodman diagram and fatigue safety factor (FSF) were analyzed to explore the effects of plaque composition on fatigue performance of a carotid stent in the stent service process. In the stent crimping-expansion process, the von Mises stress in the stent and the dog-boning ratio in Model 1 were higher than that in Model 2. The calcified plaque prevented the stent from expanding the stenotic vessel to a pre-set diameter. Thus, the risk of rupture in the calcified plaque was higher than that in the hypo-cellular plaque. Plaque also affected the stress/strain in the vessel wall, which was observed to be lower in Model 1 than in Model 2. This indicated that calcified plaque could decrease the stress-induced injury of arterial tissues. Within the stent service process, the stents used in these two models were predicted to not fail under fatigue rupture as calculated by the Goodman diagram. Additionally, the points closer to the fatigue limit were generally observed at the inner bend of the stent crowns. The FSF of the stent in Model 1 was lower than that in Model 2. The stent operating in the presence of calcified plaques suffered high risk of fractures. Reliability and fatigue performance of the stent were found to be associated with plaque composition. Hence, this study may provide stent designers an approach toward enhancing the mechanical reliability of a stent. |
关键词 | Plaque composition biomechanical carotid stent |
DOI | 10.31614/cmes.2018.04135 |
URL | 查看原文 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000447242900007 |
关键词[WOS] | FATIGUE LIFE ANALYSIS ; ATHEROSCLEROTIC PLAQUES ; CORONARY STENT ; FSI MODELS ; FRACTURE ; ARTERY ; CALCIFICATION ; ANGIOPLASTY ; RESTENOSIS ; MECHANICS |
WOS研究方向 | Engineering, Multidisciplinary ; Mathematics, Interdisciplinary Applications |
WOS类目 | Engineering ; Mathematics |
项目资助者 | Major Project of Science and Technology of Beijing Municipal Education Commission ; Type B Project of Beijing Natural Science Foundation [KZ201710005007] |
论文分区 | Q4 |
力学所作者排名 | 2 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/78154 |
专题 | 职能与支撑部门 |
作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100022, Peoples R China 2.Chinese Acad Sci, Inst Mech, 15 BeiSiHuanWest Rd, Beijing 100190, Peoples R China 3.Tohoku Univ, Grad Sch Biomed Engn, Sendai, Miyagi, Japan |
推荐引用方式 GB/T 7714 | Cui XY,Ren QS,Li ZH,et al. Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study[J]. CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,2018,116,3,:455-469. |
APA | Cui XY.,任庆帅.,Li ZH.,Peng K.,Li GY.,...&Qiao AK.(2018).Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study.CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES,116(3),455-469. |
MLA | Cui XY,et al."Effect of Plaque Composition on Biomechanical Performance of a Carotid Stent: Computational Study".CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES 116.3(2018):455-469. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
irJ2018083.pdf(2907KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
IrJ2018377.pdf(2907KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
个性服务 |
推荐该条目 |
保存到收藏夹 |
查看访问统计 |
导出为Endnote文件 |
Lanfanshu学术 |
Lanfanshu学术中相似的文章 |
[Cui XY]的文章 |
[任庆帅]的文章 |
[Li ZH]的文章 |
百度学术 |
百度学术中相似的文章 |
[Cui XY]的文章 |
[任庆帅]的文章 |
[Li ZH]的文章 |
必应学术 |
必应学术中相似的文章 |
[Cui XY]的文章 |
[任庆帅]的文章 |
[Li ZH]的文章 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论