IMECH-IR  > 先进制造工艺力学实验室
Alternative TitleStudy of bone mechanics simulation method and application on the treatment of osteonecrosis of the femoral head
Thesis Advisor王红才
Degree Grantor中国科学院大学
Place of Conferral北京
Degree Discipline工程力学


    然而,骨是一种多孔分级结构,具有非均质、非连续的特点,且个体差异性大。因此其力学模拟极为复杂。为实现上述研究目标,本文在前人基础上对股骨头模拟的分区域弹塑性方法(Subregional Method with Elastoplasticity, SMEP)进行了改进与发展,建立了一种更适合松质骨的力学模拟方法,重点分析解答了以下3方面问题:





Other Abstract

  Osteonecrosis of femoral head is one of the common diseases that cause hip joint disability. In recent years, the incidence of the disease increases gradually and the patients tend to be younger. Currently, A method using stem cells to treat necrotic bone tissue in the early stage of osteonecrosis of the femoral head is being studied. To avoid collapse of the femoral head, one of the key questions is how to effectively support the necrotic site before the new bone grows. Therefore, this paper proposes that bovine cancellous bone is used as a mechanical support and a carrier for stem cell implantation. To achieve the best support effect, the mechanical properties of the femoral head/support coupling system are simulated by finite element method.

  However, bone is a porous hierarchical structure with heterogeneous features and large individual differences. So, the mechanical simulation of bone is extremely complicated. In order to achieve the above research goals, the Subregional Method with Elastoplasticity (SMEP) is improved and developed, which is more suitable for cancellous bone mechanical simulation. Three main problems are solved as following:

  (1) The bone-like models are established based on the triply periodic minimal surfaces. The mechanical simulation shows that the yielding of the bone-like structural material should be defined by the yield strain instead of the yield stress.

  (2) The reason that cancellous bone with the same bone density but different anatomical sites has different elastic modulus is explained from the microscopic structure level.

  (3) Through the compression experiment and simulation of bovine cancellous bone, the failure softening mechanism is introduced in the SMEP method, which is more consistent with the actual characteristics of cancellous bone.

  Then, the effectiveness of the improved SMEP is verified by the large-scale spherical indentation experiment of the femoral head. It is also found that the simulation results are more in line with the actual situation of collapse and failure of cancellous bone after large deformation by using the improved SMEP.

Finally, this simulation method is applied to the treatment of osteonecrosis of femoral head. Considering the limitations of surgical procedures, different mechanical support schemes are designed for different types of osteonecrosis of femoral head. The mechanical properties of the femoral head/support coupling system are simulated and calculated. It is concluded that among the supporting schemes of osteonecrosis of the femoral head discussed in this paper, for type C osteonecrosis of femoral head, the supporting effect is the best if bovine bone column close to the weight-bearing area and is relatively thin, while for type L osteonecrosis of femoral head, the supporting effect is the best if bovine bone column close to the weight-bearing area and is relatively thick. These results provide a basis for developing surgical plans.

Call NumberMas2019-020
Document Type学位论文
Recommended Citation
GB/T 7714
王素芳. 骨力学模拟方法及其在股骨头坏死治疗中的应用研究[D]. 北京. 中国科学院大学,2019.
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