IMECH-IR  > 非线性力学国家重点实验室
Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4
Du J; Fan YL; Guo Z; Wang YG; Zheng X(郑旭); Huang C; Liang BH; Gao LY; Cao YP; Chen YP; Zhang X; Li L; Xu LP; Wu CY; Weitz DA; Feng XQ
Source PublicationCELL SYSTEMS
2019-08-28
Volume9Issue:2Pages:214-+
ISSN2405-4712
Abstract

Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the colony surface through the contraction of a three-dimensional supracellular actomyosin cortex (3D-SAC). Disruption of the 3D-SAC, whose organization is dependent on the Rho/Rho-associated kinase (ROCK) signals and E-cadherin, results in mESC colony destruction. Reciprocally, compression force, which is generated by the 3D-SAC, promotes colony growth and expression of Nanog and Oct4 in mESCs and blastocyst development of mouse embryos. These findings suggest that autonomous cell forces regulate embryonic stem cells fate determination and provide insight regarding the biomechanical regulation of embryonic development.

DOI10.1016/j.cels.2019.05.008
Indexed BySCI
Language英语
WOS IDWOS:000483697600009
WOS KeywordRHO-ASSOCIATED KINASE ; MYOSIN ; PHOSPHORYLATION ; MECHANICS ; STIFFNESS ; FRET
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
Funding ProjectNational Key R&D Program of China[2017YFA0506500] ; National Natural Science Foundation of China[31370018] ; National Natural Science Foundation of China[11620101001] ; Fundamental Research Funds for the Central Universities[ZG140S1971] ; NSF[DMR-1708729] ; Harvard MRSEC[DMR-1420570]
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; NSF ; Harvard MRSEC
Classification一类
Ranking5
ContributorDu, Jing ; Weitz, David A. ; Feng, Xiqiao
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/79937
Collection非线性力学国家重点实验室
Recommended Citation
GB/T 7714
Du J,Fan YL,Guo Z,et al. Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4[J]. CELL SYSTEMS,2019,9(2):214-+.
APA Du J.,Fan YL.,Guo Z.,Wang YG.,Zheng X.,...&Feng XQ.(2019).Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4.CELL SYSTEMS,9(2),214-+.
MLA Du J,et al."Compression Generated by a 3D Supracellular Actomyosin Cortex Promotes Embryonic Stem Cell Colony Growth and Expression of Nanog and Oct4".CELL SYSTEMS 9.2(2019):214-+.
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